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The FDA has approved the first fixed-dose combination product for the treatment of type 2 diabetes and hypercholesterolemia. This tablet combines a dipeptidyl peptidase-4 inhibitor (sitagliptin) and a HMG-CoA reductase inhibitor (simvastatin).
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In a large randomized trial of healthy men, dietary supplementation with vitamin E (400 IU/day) significantly increased the risk of prostate cancer.
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In a large community-based cohort of older women, those who self-reported use of multivitamins, vitamin B6, folate, iron, magnesium, zinc, and copper were more likely to die than those who do not. Calcium use, however, was associated with reduced risk.
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The presence of any observed hostility at baseline was associated with a two-fold increased risk of incident ischemic heart disease over a 10-year period of observation.
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The lead II rhythm strip shown above was obtained from a woman with new-onset palpitations. How would you interpret this tracing? How certain are you of your answer? Clinically what would you do?
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The decode data (diabetes epidemiology Collaborative Analysis of Diagnostic Criteria in Europe) indicated that all-cause mortality, as well as cardiovascular (CV) events, were better predicted by postprandial glucose (PPG) than fasting blood glucose (FPG).
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It would be fair to say that nearly all formal clinical research begins before it is even recognized as such. Observant clinicians note patterns, or what appear to be patterns, in those they treat.
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Death by suicide is a significant occupational hazard for physicians. This is strongly associated with professional burnout, which is characterized by a loss of emotional, mental, and physical energy due to continued job-related stress. Studies have identified three factors that are independently associated with burnout for both surgeons and internal medicine physicians hours worked per week, experiencing a work/home conflict within the last three weeks, and how the most recent work/home conflict was resolved.
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The oral administration of 500,000 IU cholecalciferol in fall or winter resulted in a slightly higher risk of falls and fractures vs placebo in 2,256 community-dwelling women aged 70 and above.
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In a lengthy intervention trial, antibiotic prophylaxis against recurrent urinary tract infections in premenopausal women was more effective than a cranberry extract; however, development of antibiotic resistance was significant.