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There has been enormous controversy regarding the benefit/safety relationship of the COX-2 inhibitors, which were initially introduced in 1999. This is a cautionary tale.
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Concealed renal insufficiency is common and contributes to adverse drug reactions from hydrosoluble medications.
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Nesiritide, Scios' intravenous recombinant form of human B-type naturetic peptide, has been widely used for the treatment of congestive heart failure in hospitalized patients. That may change with the publication of a new study that suggests that patients with acutely decompensated heart failure treated with nesiritide have a higher death rate at 30 days compared with patients who are not treated with the drug.
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The lead II rhythm strip shown in the Figure was obtained from an older man with ischemic cardiomyopathy. This asymptomatic 10-beat run of anomalous complexes was felt to be too irregular for VT (ventricular tachycardia). Do you agree?
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Because many of the clinical consequences of hemochromatosis are able to be reversed, or at least halted by appropriate treatment (phlebotomy), it is important to heighten clinician awareness of the disorder.
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The recently published ACC/AHA guidelines for the management of hyperlipidemia have elicited considerable controversy, particularly for the movement away from targeting LDL levels and for the perceived raising of the indications for statin therapy.
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Meditation and exercise interventions were shown to reduce the frequency, duration, and symptom severity of acute respiratory illness in adults aged 50 and older compared to a waitlist control group.
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The incidence of obesity continues to rise. According to the World Health Organization, 1.5 billion people are overweight, with 300 million obese.1 About two-thirds of the U.S. population is overweight, with one-third being obese.2
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Alpha-tocopherol is the primary form of vitamin E used in dietary supplements. The results from this study suggest that supplementation with alpha-tocopherol by postmenopausal women may reduce serum gamma-tocopherol levels and negatively impact bone formation.
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A meta-analysis of 20 human randomized, controlled clinical trials of at least 1 year in duration found that there was no relationship between diet or supplement-derived omega-3 supplementation and cardiovascular disease outcomes.