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A meta-analysis of eight randomized controlled trials (n = 2,426) of supplemental vitamin D showed a dose of 700-1,000 IU/d reduced fall risk in older individuals by 19% (or by 26% with vitamin D...
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In women with primary or secondary adrenal insufficiency, a meta-analysis found a small beneficial effect of DHEA supplementation on health-related quality of life and depression, but no significant effect on anxiety or sexual function.
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In this re-examination of data from the large GEM study of Ginkgo biloba in elderly subjects and incident dementia, the investigators suggest that ginkgo not only does not prevent the development of dementia, but also does not slow the rate of cognitive decline in old age.
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When an older patient lies obliquely (at an angle) when asked to lie on a bed, he or she may be developing dementia.
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Recurrent peptic ulcer bleeding was increased in patients with known cardiovascular or cerebrovascular disease when daily low-dose aspirin was continued along with proton-pump inhibitors, but overall mortality was significantly less during the 8-week follow-up.
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Low-level lead intoxication, known to adversely affect young children's cognitive development and behavior, may also harm young adults.
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The FDA has approved tranexamic acid, an antifibrinolytic drug, for the treatment of cyclic heavy menstrual bleeding.
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Losartan 150 mg/day reduced left ventricular ejection fraction, intolerance to ACE inhibitors, and the rate of death and/or hospital admission for heart failure in patients with CHF more than did losartan 50 mg/day, thereby demonstrating the potential value of uptitrating ARB doses to confer clinical benefit.
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After 1 year, fewer than half of patients presenting with fatigue will have a diagnosis.
