Dermatology
RSSArticles
-
Dietary Flavanols from Cocoa Improve Dentate Gyrus Function and Cognitive Performance in Aging Population
Decline in functional integrity of the dentate gyrus, a hippocampal region, has been observationally seen with aging.1 However, beyond these correlations, direct association between cognitive decline, dentate gyrus function, and the effects of non-pharmacological interventions has not been demonstrated.
-
Managing Stress to Improve GERD Symptoms
The researchers’ goal was to address the fact that therapies that are adjunctive to proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD) have been under studied. In this clinical trial, an education intervention was examined in adult patients with GERD recruited from rural general practices in England. -
Testosterone Therapy – Recommendations Resulting from Two Recent Clinical Trials
The prescription rate of testosterone therapy has increased dramatically in the last decade, and primary care practitioners are asked on a daily basis about testosterone supplementation. Ingenious marketing has led many patients — many of whom are older and have risk factors for heart disease — to question if testosterone therapy is right for them. -
Clinical Briefs
Johnston BC, et al. Comparison of weight loss among named diet programs in overweight and obese adults: A meta-analysis. -
Updates and Future Direction on Medical Uses for Probiotics
The probiotic movement is rapidly growing and, although to date no probiotics have been approved by the FDA, they are actively marketed to the public as either foods or dietary supplements. It behooves the primary care physician to be familiar with the science, indications, and appropriate usage of probiotic therapies. -
Aspirin for the Prevention of Recurrent Venous Thromboembolism
Patients with unprovoked venous thromboembolism (VTE) are at high risk of recurrence after discontinuation of vitamin K antagonist (such as warfarin) therapy, with an approximately 10% risk of recurrence within the first year and 5% risk per year thereafter. -
Probiotic Supplementation Reduces Upper Respiratory Tract Infections
This 150-day, randomized, double-blind, placebo controlled trial (RCT) with 465 healthy adult volunteers (mean age 37 years old) was designed to examine the effects of probiotics on the incidence of upper respiratory tract infections (URTI). -
Pirfenidone Capsule (Esbriet®) and Nintedanib Capsules (Ofev®)
The FDA has approved two drugs for the treatment of idiopathic pulmonary fibrosis (IPF). Pirfenidone is an antifibrotic agent and nintedanib is a tyrosine kinase inhibitor. Both products were approved on a fast-track priority review, with orphan status and breakthrough designation. Pirfenidone is marketed by InterMune as Esbriet and nintedanib as Ofev by Boehringer Ingelheim. -
Clinical Briefs
Effects of Losartan on Cardiovascular Morbidity and Mortality in Patients with Isolated Systolic Hypertension and LVH; Increase in Nocturnal Blood Pressure and Progression to Microalbuminuria in Type 1 Diabetes; HRT, Lipid, and Glucose Metabolism in Diabetic and Nondiabetic Postmenopausal Women -
Pharmacology Update:Ezetimibe (Zetia — Schering): A New Cholesterol-Lowering Medication
The FDA has approved Ezetimibe, the first drug in a new class of cholesterol-lowering medications.