Dermatology
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Dietary Flavanols from Cocoa Improve Dentate Gyrus Function and Cognitive Performance in Aging Population
Decline in functional integrity of the dentate gyrus, a hippocampal region, has been observationally seen with aging.1 However, beyond these correlations, direct association between cognitive decline, dentate gyrus function, and the effects of non-pharmacological interventions has not been demonstrated.
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Massage for Neck Pain: How Much Is Optimal?
This study was performed to assess the optimal amount of time massage should be used to improve neck pain in individuals suffering from chronic (> 3 months), non-specific neck pain. A total of 228 participants were randomized to one of six study groups (approximately 38 participants in each). -
Pay Attention! Tai Chi Can Help
Synopsis: A 15-week course in tai chi improved attention scores in healthy university students.
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Updates and Future Direction on Medical Uses for Probiotics
The probiotic movement is rapidly growing and, although to date no probiotics have been approved by the FDA, they are actively marketed to the public as either foods or dietary supplements. It behooves the primary care physician to be familiar with the science, indications, and appropriate usage of probiotic therapies. -
Clinical Briefs
Johnston BC, et al. Comparison of weight loss among named diet programs in overweight and obese adults: A meta-analysis. -
Pirfenidone Capsule (Esbriet®) and Nintedanib Capsules (Ofev®)
The FDA has approved two drugs for the treatment of idiopathic pulmonary fibrosis (IPF). Pirfenidone is an antifibrotic agent and nintedanib is a tyrosine kinase inhibitor. Both products were approved on a fast-track priority review, with orphan status and breakthrough designation. Pirfenidone is marketed by InterMune as Esbriet and nintedanib as Ofev by Boehringer Ingelheim. -
Probiotic Supplementation Reduces Upper Respiratory Tract Infections
This 150-day, randomized, double-blind, placebo controlled trial (RCT) with 465 healthy adult volunteers (mean age 37 years old) was designed to examine the effects of probiotics on the incidence of upper respiratory tract infections (URTI). -
Aspirin for the Prevention of Recurrent Venous Thromboembolism
Patients with unprovoked venous thromboembolism (VTE) are at high risk of recurrence after discontinuation of vitamin K antagonist (such as warfarin) therapy, with an approximately 10% risk of recurrence within the first year and 5% risk per year thereafter. -
When to Order a Sleep Study and How to Read the Report: Part II
Understanding the information provided in a sleep study report and knowing how to use it is crucial for accurate diagnosis and effective treatment. The combined information from the sleep history and the sleep report allows diagnosis of all sleep disorders. -
Pharmacology Watch: High-Dose Rofecoxib Confirmed Prothrombotic, Study Shows
Debate over the cardiovascular effects of COX-2 inhibitors has raged for more than a year since a special communication was published in JAMA last August suggesting an increase in cardiovascular events with rofecoxib (Vioxx). Now a large retrospect, the cohort study from the Tennessee Medicaid program seems to confirm the prothrombotic effects of rofecoxib, at least in high dose.