Dementia/Alzheimer Disease
RSSArticles
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The Incidence of Dementia May Be Declining
In community-dwelling people from Bronx County, New York, there was a sharp decrease in dementia incidence in those born after mid-1929, which could not be readily explained by changes in the prevalence of cardiovascular diseases, higher education, or increased racial/ethnic diversity.
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REM Sleep, Not Slow-wave Sleep, Decreases Dementia Risk
In a series of clinical studies of cognitively normal people older than 60 years of age, disruption of REM sleep and reduced quantity of REM sleep increased the risk of developing Alzheimer-type dementia.
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P-syn in Nerve Fibers on Skin Biopsy May Help Diagnose Dementia with Lewy Bodies
This study compared 18 subjects diagnosed with dementia with Lewy bodies (DLB), 23 with nonsynucleinopathy dementia, and 25 healthy controls and demonstrated that phosphorylated alpha-synuclein was found only in the skin nerve fibers of DLB subjects, helping distinguish this type of dementia from other types.
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Is Sleep a Clue to a Modifiable Risk Factor for Alzheimer’s Disease?
Evidence is accumulating that disruptions in sleep patterns, particularly slow-wave and REM sleep, alter amyloid-β production and clearance through the cerebrospinal fluid pathways and may play a role in the development of Alzheimer’s disease.
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Severe Olfactory Impairment Is Associated With Preclinical Alzheimer’s Disease
In this cross-sectional, population-based, cohort study of 829 cognitively normal participants, abnormal neuroimaging biomarkers known to be associated with Alzheimer’s disease were associated with severe olfactory impairment.
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Omega-3 Polyunsaturated Fatty Acid Supplementation and Cognitive Decline
In a randomized, placebo-controlled trial of 1,680 participants aged 70 years or older, there was no significant difference in cognitive decline between any of the intervention groups taking omega-3 polyunsaturated fatty acid supplementation and/or multidomain intervention (physical activity, cognitive training, and nutritional advice) compared to the placebo group. However, exploratory post hoc analyses showed some promise for a protective effect with intervention in certain at-risk subgroups.
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Alzheimer’s Prevention: No Harm in ‘Forgetting’ Vitamin E and/or Selenium
This large-scale study of asymptomatic elderly men reveals no indication that selenium or vitamin E (taken alone or in combination) prevents development of dementia.
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Alzheimer’s Disease Deaths Increased 55% Since 1999
The rate of deaths from Alzheimer’s disease increased 54.5% over 15 years, according to a new CDC report
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Dementia Updates for Primary Care Providers
The diagnostic criteria for Alzheimer’s disease (AD) have changed in recent years, with a growing focus on pathologic and genetic biomarkers. The diagnosis itself now is divided into three distinct stages: the preclinical stage, mild cognitive impairment, and clinical AD. Dementia is a common and growing problem that is associated with significant caregiver burden and immense cost. A growing focus on disease prevention and management of risk factors in mid-life is vital to attempt to mitigate the daunting impact of this illness on patients, caregivers, and the healthcare system as a whole.
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Vascular Risk Factors and Their Role in the Development of Alzheimer’s Disease
This study has found an association between mid-life, but not late-life, vascular risk factors and brain amyloid deposition as imaged on amyloid-labeled PET.