Critical Care
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Duration of Antibiotic Treatment for Vertebral Osteomyelitis
Three hundred fifty-nine patients with pyogenic vertebral osteomyelitis were randomized to 6 weeks vs. 12 weeks of antibiotic treatment in an open-label controlled trial. Six weeks of antibiotics was found to be not inferior to 12 weeks of treatment.
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VTE Occurs Frequently in Patients with Sepsis
The purpose of this multicenter study was to prospectively determine the incidence of VTE among ICU patients with sepsis and septic shock, and to identify independent risk factors for VTE in these patients.
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Inferior Vena Cava Filters and Recurrent Pulmonary Embolism
Placement of retrievable inferior vena cava filters in individuals with concurrent DVT does not reduce the risk of recurrent pulmonary embolism.
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When Do Ventilator Modes Matter?
Although pressure-controlled ventilation and volume-controlled ventilation approach mechanical breath delivery differently in terms of inspiratory flow and airway pressure characteristics, this comprehensive review found no significant differences in terms of their impact on breathing mechanics or gas exchange in patients with various forms of acute respiratory failure.
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Inferior Vena Cava Filters and Recurrent Pulmonary Embolism
Even in patients who seem most vulnerable to additional embolism, retrievable inferior vena cava filter placement plus anticoagulation did not improve outcomes vs. anticoagulation alone.
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Decreasing Cross-Transmission of Carbapenemase-Producing Enterobacteriaceae
The implementation of a bundled infection control intervention was able to significantly decrease cross-transmission of a multi-drug-resistant pathogen and decrease healthcare-associated infections in an long-term acute care hospitals population.
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Is Fresh Blood Better?
The Age of Blood Evaluation trial supports the notion that the relative expiration date of red blood cells is not important.
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See No Lights, Hear No Alarms: Sleeping in the ICU
ABSTRACT & COMMENTARY: Sleep quality in the ICU can improve. Here's how.
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Risk of NSAID use in patients receiving antithrombotic therapy after myocardial infarction
Among patients receiving antithrombotic therapy after MI, the use of NSAIDs was associated with increased risk of bleeding and excess thrombotic events, even after short-term treatment.
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Early, goal-directed therapy of septic shock
One thousand two hundred sixty patients with early septic shock were randomized to early, goal-directed therapy vs. usual care. Hemodynamic management according to a strict protocol did not lead to an improvement in outcome.