Critical Care
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Optimal Duration of Anticoagulation for Unprovoked Pulmonary Embolism
The PADIS-PE study is a randomized, double-blind trial of adult patients with a first episode of unprovoked PE that seeks to better define the appropriate duration of therapy.
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Oral Nutritional Supplementation for Hospitalized COPD Patients Pays Off
<>In contrast to many of the other top 10 causes of death in the United States, COPD deaths are increasing, such that COPD is now the third most common cause of death. Although a variety of pharmacologic interventions are available to improve symptoms and decrease exacerbations, none has been shown to reduce mortality. -
Tighter Blood Pressure Control Post-Intracranial Hemorrhage May Decrease Recurrence
Fifty percent of stroke-related morbidity and mortality are related to intracerebral hemorrhage.
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National Practice Patterns and Outcomes of Tracheostomy Placement in the United States
Tracheostomy use rose over the last two decades until 2008 in the United States and was associated with an increase in discharge to long-term care facilities with a concomitant decrease in hospital length of stay and hospital mortality.
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Should High-flow Oxygen Therapy Change Our Approach to Managing Acute Respiratory Failure?
Managing acute hypoxemic respiratory failure with high-flow nasal cannula significantly reduced intubation rates compared to standard oxygen (O2) mask delivery and non-invasive ventilation among patients whose arterial O2 tension to inspired O2 fraction ratio (PaO2/FiO2) was < 200.
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Achieving Successful Rehabilitation in the ICU
Clinicians should consider ICU-acquired weakness in almost every critically ill patient who is ventilated.
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Does Bacteremia Associated with Bone and Joint Infections Require Prolonged IV Antibiotic Therapy?
Two hundred sixty-five previously healthy children with culture-proven acute bone or joint infection (age range 3 months to 15 years) were studied. -
A Modern Epidemiologic View of Status Epilepticus in the United States
Although definitions have changed, status epilepticus is presently defined as a prolonged seizure or multiple seizures with incomplete return to baseline function lasting longer than 5 minutes. -
Antibiotics for Acute Appendicitis
Appendectomy has been the treatment for acute appendicitis since the late nineteenth century. During the past decade, the notion of treating acute appendicitis with antibiotics alone has been proposed and evaluated in several clinical trials. However, these trials have been criticized because of methodological limitations.
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Is Peripheral Intravenous Administration of Vasopressors Really Safe?
Vasoactive medications are most commonly administered through central venous catheters