Critical Care
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Surviving Critical Illness: Who Returns to Work?
Three months after surviving critical illness due to respiratory failure or shock, more than 60% of survivors experienced a decrease in employment. At 12 months, almost half of survivors still experienced a decrease in employment.
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ECMO as a Rescue Strategy for Severe ARDS and Beyond
Extracorporeal membrane oxygenation has been used as a rescue therapy for patients with severe acute respiratory distress syndrome who fail to respond to traditional low tidal volume lung protective ventilation with optimal positive end-expiratory pressure interventions and other strategies.
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Tactical Emergency Medicine
Mass casualty shooting events in the United States, although rare, appear to be increasing in frequency. Active shooter attacks have become a favored means of inflicting terror attacks. This article has the purpose of speeding the transition of military medical lessons learned from the battlefield to civilian medical response to high-risk situations.
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Strategies to Manage the Failed Airway
In this large, multicenter, retrospective study, video laryngoscopy, the most common approach to failed airway management, demonstrated a high rate of success, even when difficult ventilation existed.
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Antibiotic Treatment in Community-acquired Pneumonia
In patients with newly diagnosed community-acquired pneumonia, basing the duration of antibiotic treatment on clinical stability criteria led to a significant reduction in duration of antibiotic treatment without an increased risk of adverse outcomes.
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Is There an Optimal Blood Pressure Target in Patients Presenting with Intracerebral Hemorrhage?
Recently, two large randomized, controlled trials compared intensive blood pressure control with permissive hypertension in the setting of acute intracerebral hemorrhage. The authors of the two trials reached seemingly differing conclusions, leading to confusion on how to best manage patients.
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Sacubitril/Valsartan Associated with Reduced Risk of Hyperkalemia
\In a secondary analysis of the PARADIGM-HF trial, the risk of severe hyperkalemia in heart failure patients taking a mineralocorticoid receptor antagonist was lower among patients treated with sacubitril/valsartan compared to those receiving enalapril.
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Zika Virus Infection and Guillain-Barré Syndrome: The Evidence Grows
A recent Zika outbreak in Colombia was associated with a significant increase in Guillain-Barré syndrome (GBS) rates, with laboratory evidence of definite or probable Zika infection in more than half of the GBS cases.
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Early Initiation of Continuous Renal Replacement Therapy May Reduce Mortality in Patients Who Require Dialysis
Initiation of continuous renal replacement therapy for patients with Kidney Disease: Improving Global Outcomes stage 2 renal failure reduced 90-day all-cause mortality.
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Bezlotoxumab Injection (Zinplava)
The FDA has approved a selective, fully human monoclonal antibody directed at Clostridium difficilie toxin B. Binding of toxin B neutralizes its toxic effect. Bezlotoxumab is marketed as Zinplava.