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The role of intensive antiplatelet therapy for prevention of vascular events in patients with atrial fibrillation remains controversial. The Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events (ACTIVE) trio of studies is an attempt to clarify this issue.
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A randomized study of treatment of septic arthritis in children 3 months to 15 years of age demonstrated that 10 days of treatment, with an initial 2-4 days intravenously followed by oral therapy, was sufficient for most cases, regardless of the infecting pathogen or site of infection.
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Adenovirus 14 (Ad14) has emerged as a cause of febrile respiratory illness (FRI) and has resulted in pneumonia in a significant number of patients.
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The combination of aspirin with clopidogrel is better than aspirin alone in reducing the risk of stroke in patients with atrial fibrillation.
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The differential diagnosis of acute chest pain includes three entities that can be lethal if missed: myocardial infarction (MI), pulmonary embolus, and aortic dissection.
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Methicillin-resistant Staphylococcus aureus (MRSA) has reached almost mythic status. It has come to mean much more than an isolate of S. aureus that happens to be resistant to methicillin, an antibiotic that is no longer in clinical use. It is a slap in the face of humankind's efforts to rein in infectious illness.
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This large multicenter, randomized, controlled parallel-group trial found that intensive glucose management, compared to conventional (target glucose 81-108 mg/dL vs. ≤ 180 mg/dL), increases 90-day mortality in both medical and surgical ICU patients.