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Denosumab is a new human monoclonal antibody that suppresses osteoclast function and thus inhibits bone resorption.
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The FDA is requiring new boxed warnings on TNF-blockers regarding the risk of lymphoma and other malignancies in children and adolescents who have received the drugs.
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The World Health Organization (WHO) has issued a global alert and response regarding the use of antivirals for pandemic H1N1 flu, reiterating that antivirals should be used to prevent severe illness and death in children and adults.
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Physicians are prescribing fewer antibiotics for acute respiratory tract infections (ARTIs), but if an antibiotic is used, it is more likely to be a broad-spectrum drug.
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In order to reduce the rate of catheter-related bloodstream infections (CRBSIs) in intensive care units, Northwestern Memorial Hospital implemented patient-care bundles in all ICUs in August 2005.
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This study showed that cleaning a stethoscope with an ethanol-based foam hand cleaner is as effective as wiping it with an isopropyl alcohol pad.
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In this paper, Krahn et al, from a Canadian consortium, report on the results of systematic evaluations in patients with unexplained cardiac arrest due to ventricular tachycardia or ventricular fibrillation.
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The concept of abandoning the use of whole blood in favor of packed cells for the treatment of hypovolemia in obstetric hemorrhage should be questioned in view of this study's suggestion of a lower rate of acute tubular necrosis in patients treated with whole blood.
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In January 2009, the publication of an updated vancomycin monitoring guideline gave clinicians a set of recommendations on: 1) timing of monitoring, 2) optimal trough concentration, 3) dosing to achieve optimal trough concentrations, 4) loading doses for complicated infections, 5) criteria for monitoring, and 6) frequency of monitoring.
