Recombinant Panton-Valentine leukocidin (PVL) toxins showed lytic activity against human (but not murine) neutrophils. The lytic activity of culture supernatants of USA400 and USA300 strains of MRSA were completely neutralized by anti-PVL monoclonal antibodies. In contrast, phenol-soluble modulin alpha3 (PSM) failed to lyse human neutrophils but did enhance PVL-mediated neutrophil lysis.
Dabigatran etexilate is an oral compound that is converted after absorption by a serum esterase to dabigatran, a direct competitive inhibitor of thrombin.
Current indications for cardiac-resynchronization therapy (CRT) require that patients have New York Heart Association (NYHA) Class III or Class IV heart-failure symptoms.
Change is sometimes difficult to detect, especially if it happens gradually. Psychologists call it creeping normalcy. With slow change, we become conditioned with each incremental step and do not appreciate the overall change. Then, sometimes, when we stop and look back, we are struck with the contrast.
In addition to their cholesterol-lowering properties, hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, commonly referred to as statins, have been shown to modify inflammatory and immunologic pathways.
Prevention of ventilator associated pneumonia (VAP) is a key area of focus for promoting quality of care in the intensive care unit (ICU) and best patient outcomes.
