Critical Care Topics
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Driving Pressures More Strongly Predicted Survival than P/F Ratios in Patients with ARDS
Optimizing positive end-expiratory pressure to minimize driving pressure may be a better strategy for ventilator adjustment than maximizing partial pressure of arterial oxygen/fraction of inspired oxygen (P/F) ratios to improve outcomes in patients with acute respiratory distress syndrome. -
Elucidating the Long-Term Effects of COVID-19
In this prospective uncontrolled cohort study of COVID-19 survivors performed four months after their hospitalization, many patients reported at least one symptom not previously present, and abnormalities on lung computed tomography scan were common. -
High Pleural Pressure Prevents Overdistension in ARDS Patients with High Body Mass Index
High airway pressure is required to recruit lung atelectasis in patients with acute respiratory distress syndrome and body mass index ≥ 35 kg/m2. -
Use Push-Dose Phenylephrine with Caution in Septic Patients
Phenylephrine pushes in septic patients were associated with early hemodynamic stability, but higher intensive care unit mortality.
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The Effect of Antiviral Drugs on COVID-19 Outcomes and Mortality
The WHO Solidarity Trial Consortium found that remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had “little or no effect” on relevant outcomes. -
Prone Positioning May Improve Outcomes for Patients on ECMO for Severe ARDS
In patients on venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome, prone positioning is safe and feasible. Prone positioning appears to improve survival but increases length of stay. -
Ethics in the ICU: Negotiating Requests for Inappropriate Treatments
When requests for potentially inappropriate treatments occur, the initial steps include increasing communication and improving mutual understanding to find a path that is appropriate while honoring the goals and concerns expressed by patients and their families. -
COVID-19 Patients Can Be Managed Safely with Noninvasive Respiratory Techniques
In adult patients hospitalized with COVID-19 for one month, using a noninvasive respiratory protocol that encouraged high-flow nasal cannula, noninvasive mechanical ventilation, and self-proning did not result in any significant increase in mortality.
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Pressure Support Compared to T-Piece Trial: What Is the Optimal Strategy?
Post-hoc analysis of a multicenter, randomized clinical trial among adults receiving at least 24 hours of mechanical ventilation who were ready for ventilator weaning revealed that the use of pressure support significantly increased the proportion of patients successfully extubated compared to T-piece.
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Management of the Cardiac Surgery Patient
The goal of this review is to provide an evidence-based narrative for the management of post-operative patients who have coronary artery bypass graft surgery and heart valve repair/replacement surgeries.