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Associations between the number of patients managed (hospital volume) and improved patient survival have been extensively documented in the surgical literaturesuch as cardiac surgery, ruptured aortic aneurysm, and several types of cancer surgeryand suggested for selected medical conditions, such as acute myocardial infarction and the acquired immunodeficiency syndrome.
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Over a 3-month period, all patients who required mechanical ventilation in the ICU of Tygerberg Academic Hospital in Cape Town, South Africa, were enrolled in this study.
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In this study, scala and colleagues compared the clinical outcomes of patients with acute respiratory failure due to COPD exacerbations and different degrees of altered levels of consciousness.
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Investigators at the university of amsterdam performed an extensive review of articles, retrieved via Medline, that reported ICU outcomes in very elderly patients.
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More than 20 years ago, case reports appeared in the literature describing a neuromuscular abnormality that developed as a consequence of critical illness.
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In this randomized-controlled trial, Koeman and associates wanted to determine the effect of two oral decontaminating gels, chlorhexidine 2% (CHX) or chlorhexidine 2% plus colistin 2% (CHX/COL), compared to a placebo, on the development of ventilator-associated pneumonia (VAP) in patients requiring more than 48 hours of mechanical ventilation.
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In this prospective observational study, Kollef and associates enrolled patients with ventilator-associated pneumonia (VAP) in 20 ICUs across the United States in order to characterize the patients and the antimicrobial regimens used in treating them, as well as their mortality and lengths of stay.
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In the early 2000s, substantial evidenced-based interventions were added to the care of critically ill patients that significantly reduced mortalityincluding low tidal volume ventilatory support for acute respiratory distress syndrome (ARDS), protocolized sedation with daily awakening, Drotrecogin-alpha for severe sepsis, tight glycemic control, corticosteroids for refractory septic shock and preventative strategies for ventilator associated pneumonia.
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TNF Blockers: Should You Be Concerned?; FDA Actions
