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Propylene glycol is used as the carrier vehicle for a number of drugs including lorazepam and diazepam. It may cause metabolic abnormalities such as anion gap metabolic (usually lactic) acidosis and hyperosmolality.
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Do Antidepressants Increase Risk of Suicide?; Can Viagra Improve Heart Function?; A Dramatic Increase of Clostridium difficile; FDA Actions
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Late in the evening you receive a page about a patient who is fighting the ventilator. You are cross-covering and do not know the patient. Your sign-out sheet says only that she is 68 years old, has severe COPD complicated by pneumonia, and has been in the ICU for the last 3 days. No specific problems are mentioned.
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Alternative Therapy for Depression?; FDA Actions
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A 58-year-old woman presented with 3 days of dyspnea and was shown by CT scan to have pulmonary thromboemboli. She was anticoagulated with low-molecular-weight heparin and was stable for 2 days, but then developed acute respiratory failure, was intubated, and transferred to the ICU.
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A 53-year-old woman with a history of splenectomy 15 years ago for idiopathic thrombocytopenic purpura and no chronic medical problems awoke with headache, myalgias, and fever. She was seen at her local urgent care that evening where she had a temperature of 102°F with mild tachycardia but otherwise normal vital signs.
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Infection control practices often target clinician behaviors, eg, improving adherence to hand washing hygiene and other infection control practices.
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This prospective 10-year study of 7356 patients with ST-elevation MI who presented in cardiogenic shock showed once again that early mechanical revascularization (as recommended by current guidelines) substantially increases survival; it also suggests that adherence to the guidelines needs to be further improved.