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Septic shock is one of the common causes of hypotension in the ICU. For decades, adrenergic agents with variable alpha- and beta-adrenergic activities have been the mainstay among vasopressor agents. Very few randomized controlled trials have been done that identify the efficacy or superiority of any one particular agent.
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This single-center prospective observational study reveals that the presence of 3 factors (low cough peak flow, high secretion volume, and poor neurologic score per a simple 4-task test) may be useful in predicting extubation failure.
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In surgical and trauma patients, a single oral application of 2 mL chlorhexidine gluconate was successful in reducing oral bacterial growth over a 72-hour period following intubation.
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A large multicenter prospective randomized double-blind trial found no difference in 28-day outcomes for fluid resuscitation with normal saline vs 4% albumin for a heterogeneous ICU population.
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Breast Cancer and the Use of Statins; Warnings Issued for IBS Drugs; FDA Actions
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Several factors are considered to be associated with the development of nosocomial infections in the ICU. Among them, indwelling devices that directly contact the blood and mucosal membrane such as the central venous catheter, urinary tract catheter and endotracheal tube are considered to be the most responsible risk factors in the development of nosocomial infections.
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Among 56,250 British ICU patients, hospital mortality rates were higher among those admitted on the weekend or at night, but the differences disappeared when confounding by illness severity and other aspects of case mix were eliminated.
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