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The frequency of chemotherapy-induced amenorrhea was found to be greater than 90% in premenopausal breast cancer patients treated with standard adjuvant chemotherapy.
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In a retrospective review of 2276 patients with acute myeloid leukemia (AML) treated on one of three consecutive Phase 3 studies using non-age based, standard intensive chemotherapy conducted by the Japan Adult Leukemia Study Group between 1995 and 2005, there was a significant decline in overall survival in patients aged ≥ 50 years when compared to those < 50 years.
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Medications for Risk Reduction of Breast Cancer in Women
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Evidence-based updates in primary care medicine By Louis Kuritzky, MD
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There has been much written recently about the association of diabetes and cancer.
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In an epidemiological evaluation of acute myeloid leukemia survival over 3.5 decades, dramatic improvement was demonstrable for younger patients, but not so for the elderly.
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In a large population of Caucasian women participating in the Womens Health Initiative Observational Study, those who used aspirin had a significantly lower risk of melanoma and increased duration of use was associated with incrementally greater protection.
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Carboplatin-pemetrexed doublet chemotherapy is effective primary treatment for patients with nonsquamous non-small cell lung cancer, but the applicability of standard dosing to older or more frail patients was uncertain.
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Selumetinib, a selective MEK1/2 inhibitor, achieved objective responses in 15% of patients with recurrent low-grade serous ovarian cancer. The data are relevant as this uncommon tumor type is associated with general chemoresistance, frequent aberration in the MAPK pathway, and prolonged overall survival compared with its more common high-grade variant. Phase 3 trials are planned.
