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In a six-site Italian retrospective analysis, treatment of elderly patients with metastatic renal cell carcinoma with sunitinib was shown to be effective but associated with significant toxicity. Although only applied to a subset, pretreatment comprehensive geriatric assessment did not offer predictive value with regard to severe toxicity or efficacy.
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Early pivotal trials demonstrating the efficacy of sorafenib for patients with advanced hepatocellular cancer included primarily those with minimal liver dysfunction (Child-Pugh [CP] class A).
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LAP2 was a randomized, Phase 3 trial to evaluate and compare the modality of surgical staging (laparoscopy vs laparotomy) in endometrial cancer.
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This Phase 1 clinical trial evaluated the safety and pharmacokinetics of intraventricular immune-chemotherapy with twice weekly rituximab (10 mg and 25 mg) and methotrexate in 14 patients with recurrent central nervous system lymphoma (primary or secondary).
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Aspirin use and AMD risk; using NSAIDs and antihypertensive agents; and FDA actions.
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In a randomized, Phase 2 trial, weekly maintenance cetuximab for 12 weeks after concomitant definitive radiation therapy/cetuximab induction was associated with better disease-free survival at 1 year.
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In an observational study conducted in Germany of more than 600 anemic cancer patients receiving parenteral iron (ferric carboxymaltose), hemoglobin levels were shown to rise significantly.
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Statin use among cancer patients with diverse malignancies is associated with reduced cancer-related mortality.
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A 52-year-old female presented with right flank pain, elevated bilirubin, and mild jaundice to her primary care physician. Endoscopic retrograde cholangiopancreatography demonstrated a common bile duct stricture just above the pancreatic head with a suggestion of neoplasia.
