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How Should We Manage False-Positive Myasthenia Gravis Antibody Studies?
False-positive autoantibody tests for myasthenia gravis occur in a small number of patients who undergo broad screening for autoimmune disorders affecting the peripheral and central nervous system. Careful investigation of clinical and electrophysiological features of each patient will determine the validity of these tests.
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Risk Factors and Outcomes for Post-Traumatic Seizures After Moderate to Severe Traumatic Brain Injury
Using data collected from an Australian registry, a population-based cohort study identified risk factors for early post-traumatic seizures (EPS), associated morbidity and mortality, and contribution to development of post-traumatic epilepsy (PTE). EPS were associated with significant in-hospital morbidity, poorer outcomes, and increased risk of mortality at 24 months of follow-up. Patients with EPS had a higher risk of developing PTE.
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Genetic Evaluation of Hereditary Spastic Paraplegia
Hereditary spastic paraplegia (HSP) refers to a group of rare, clinically heterogenous degenerative neurogenetic disorders resulting in spasticity, gait impairment, and falls as the result of a length-dependent upper motor neuron degeneration. Next-generation sequencing with multigene panels or exome analysis can confirm molecular diagnosis of approximately 30% of HSP patients. Multigene panels can identify the common causative variants, variants on rarely involved genes, and structural rearrangements.
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What Is This Tachycardia?
How would one interpret the tachycardia in the ECG? Is the rhythm ventricular tachycardia or some form of supraventricular tachycardia? How should one proceed?
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Tirzepatide Injection (Mounjaro)
Tirzepatide can be prescribed as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
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Mortality, Days Alive Outside Institutions Among Older Patients After Tracheostomy
Medicare beneficiaries who underwent tracheostomy and gastrostomy tube placement often remained institutionalized beyond three months, with three-, six-, and 12-month mortality greater than 40%, 50%, and 60%, respectively.
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Outpatient Management of COVID-19
The COVID-19 pandemic continues to be a major public health concern. The availability of new therapies, as well as their use, continues to be shrouded in confusion. This discussion provides a brief clinical overview of COVID-19, followed by a focus on outpatient management and therapy based on our current understanding and available therapies.
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Infectious Disease Alert Updates
How Much Should Injectable Cabotegravir for PrEP Cost? Asymptomatic COVID Infection in Healthcare Workers
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Is There Value in Repeating Blood Cultures While the First Set Is Still Incubating?
The yield from repeat blood cultures is low, suggesting their general use in most patients should be discouraged.
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Getting to the NBA Finals by COVID-19 Vaccine Boosting
Vaccine booster doses were highly effective in preventing infection, whether symptomatic or asymptomatic, with the omicron variant of SARS-CoV-2 in National Basketball Association players and staff.