Clinical
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Deucravacitinib Tablets (Sotyktu)
Deucravacitinib can be prescribed to adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
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Increasing Incidence of Stage IV Cervical Cancer
The incidence of stage IV cervical cancer in the United States between 2001 and 2018 increased. Rates were highest among Black women, but the annual rate of increase was highest among white women in the South age 40-44 years.
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Vitamin D3, Omega-3 Supplements for Older Adults to Lower Frailty Risk
Data from a large, randomized trial that included 25,871 adults age 50 years or older indicated 2,000 daily units of vitamin D3 and 1 g daily of omega-3 fatty acid supplementation did not affect frailty.
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Importance of Medication Adherence in Ischemic Heart Disease
The results of a subanalysis of the ISCHEMIA trial indicated about one-quarter of patients in both conservative and invasive strategy groups were nonadherent to recommended medical therapy at baseline. Nonadherence was associated with worse health status in both groups at baseline and after one year.
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Evidence of Clinical Efficacy of Bebtelovimab in COVID-19
In a retrospective study, bebtelovimab demonstrated efficacy similar to Paxlovid in high-risk outpatients with recent onset of COVID-19 who reported mild to moderate symptoms.
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Spironolactone May Help Treat Chronic Alcoholism
Both animal and human studies suggest spironolactone might be a new agent for helping patients with alcohol use disorder cut their intake.
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Does Shoulder Simulation Training Decrease the Incidence of Brachial Plexus Injury?
This study demonstrated that improved team and individual performance can result from systematic simulation-based shoulder dystocia training, which can considerably lower the incidence of permanent brachial plexus injuries.
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Ultrasound to Detect Endometrial Cancer and Endometrial Intraepithelial Neoplasia in Patients Without Abnormal Bleeding
In women without abnormal uterine bleeding undergoing transvaginal ultrasound, endometrial intraepithelial neoplasia or endometrial cancer was associated with a thicker endometrium, heterogenous echotexture, more frequent endometrial cysts, and increased vascularity.
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Labiaplasty in the United States
In this descriptive study, the rates of labiaplasty from 2016-2019 in the United States ranged from 3,046 to 4,315 per year and were highest among women aged 18 to 35 years.
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The Harms of Urine Drug Screening for Isolated Marijuana Use on Labor and Delivery Units
Isolated marijuana use, when used as an indication for urine drug screening during the labor and delivery period, poorly predicts concomitant use of other nonprescribed substances. However, use of the screening brings real risk of inequitable harm.