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Infectious Disease Alert Updates
Is Your Hospital Room Toxigenic?; Reduction of HOCDI — Gaming the System?
Medical Masks Compared to N95 Respirators for COVID-19 Prevention in Healthcare Workers
A multicenter, randomized, controlled study found that medical masks were noninferior to N95 respirators in their relative protection against COVID-19 among healthcare workers when worn while providing routine care to patients with suspected or confirmed COVID-19.
Inching Toward the Goal: Does Selective Decontamination of the Digestive Tract Have a Benefit for Patients on Mechanical Ventilation?
Two recent articles contribute to the ongoing discussion of whether selective decontamination of the digestive tract provides a mortality benefit for patients who are receiving mechanical ventilation.
COVID Is Not ‘Just the Flu’
Among hospitalized patients requiring oxygen support at admission, COVID-19 was three times more fatal than was influenza.
An Effective Oral Regimen for Rifampin-Resistant Tuberculosis
A multicenter, randomized, controlled, noninferiority clinical trial found a 24-week, all-oral regimen (bedaquiline, pretomanid, linezolid, and moxifloxacin) to be safe and effective for patients aged 15 years and older with rifampin-resistant tuberculosis.
A Comparison of Ceftaroline and Daptomycin in Treatment of MRSA Bloodstream Infections
Ceftaroline is an acceptable alternative therapy for treatment of methicillin-resistant Staphylococcus aureus bacteremia.
RSV Bronchiolitis Has Persisting Consequences for Some Children
Young children hospitalized with respiratory syncytial virus (RSV) infection are at increased risk of subsequent hospitalization during the following year and of increased need for outpatient healthcare.
Tocilizumab Injection (Actemra)
The FDA has approved tocilizumab injection to treat COVID-19 among hospitalized adult patients who are receiving systemic corticosteroids and require supplemental oxygen.
New Therapy for Resistant Hypertension
Aprocitentan demonstrated efficacy for additional therapy beyond standard multidrug treatment in resistant hypertension.
Is It Better to Up-Titrate Medications Faster in Acute Heart Failure Patients?
Early intensive up-titration of guideline-recommended therapy in patients admitted for heart failure reduced 180-day readmission and all-cause mortality rates at the cost of more adverse events (but not serious or fatal ones).