Clinical
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Alzheimer’s Research Funding Receives Boost
The fiscal year 2023 federal budget also includes provisions to strengthen accelerated drug approval and Alzheimer’s public health infrastructure.
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Do NSAIDs Cause More Chronic Pain?
Acute inflammation may protect against the development of chronic pain through neutrophil activation. Using nonsteroidal anti-inflammatory drugs may blunt that response and contribute to chronic pain.
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Effects of Sodium Restriction in Chronic, Stable Heart Failure Patients
A study of a low-sodium diet for chronic, stable heart failure patients after one year showed no difference in hard clinical outcomes, but the degree of sodium restriction was modest.
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Mediterranean vs. Low-Fat Diet for Secondary Prevention
A study of stable coronary heart disease patients comparing the Mediterranean diet to a low-fat diet over a seven-year follow-up showed the Mediterranean diet was superior at preventing major cardiovascular events.
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How Does Public Policy Affect Diet and Health?
The World Health Organization sponsored this systemic review and meta-analysis to analyze the effect of food subsidies and taxes on population-level changes in diet and health outcomes.
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Cerebral Amyloid Angiopathy and Brain Hemorrhage
When comparing the time course of hematoma expansion between deep hematomas and lobar hematomas from cerebral amyloid angiopathy (CAA) and other etiologies, lobar hematomas from CAA show greater expansion and a longer period of risk for hematoma growth compared to deep hematomas.
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Brain Iron Chelation with Deferiprone in Parkinson’s Disease
In a randomized, placebo-controlled treatment trial, deferiprone administered to early, levodopa-naive Parkinson’s disease patients over 36 weeks was associated with worsening of their symptoms, in spite of imaging evidence for reduction of iron in the substantia nigra.
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Body Weight Decline in Cognitively Intact Older Adults May Predict Future Cognitive Impairment
Among cognitively intact individuals, those who develop mild cognitive impairment (MCI) had faster body mass index (BMI) decline and significantly lower BMI seven years before MCI diagnosis. However, after MCI diagnosis, there was no difference in BMI decline between patients who developed dementia and those who did not.
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What Is Oculopharyngodistal Myopathy?
Distal limb myopathies are rare disorders and are difficult to diagnose. Current muscle biopsy technology, coupled with genetic analysis, offers the best hope for an accurate diagnosis of these unusual neuromuscular disorders. Unfortunately, treatments remain elusive.
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Misdiagnosis of Autoimmune Encephalitis
A recent multicenter, retrospective review of 393 adult patients given a diagnosis of autoimmune encephalitis noted that 107 patients (27%) were misdiagnosed and ultimately had other diagnoses confirmed, but after a considerable delay.