Clinical
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New Treatments for Uterine Fibroids
In this prospective, open-label, single-arm trial of 149 individuals with heavy menstrual bleeding and uterine leiomyomas, daily relugolix combination therapy (relugolix 40 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg) resulted in a mean menstrual blood loss reduction of 90%, and 70% of the participants achieved amenorrhea by the end of the 52-week period. Similar results were found for other arms of the trial among women who crossed over from placebo and relugolix-only therapy to relugolix combination therapy.
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#IUD on TikTok: An Analysis of Intrauterine Device-Related Content on Social Media
The top 100 videos on the social media platform TikTok were compiled and systematically analyzed for user demographics and video content. More videos had a negative tone, particularly those conveying patient experiences related to pain and informed consent.
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Is AV Block Complete?
Does the ECG in the figure represent complete AV block? If not, why not?
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Fecal Microbiota, live-jslm (Rebyota)
Rebyota can be prescribed to prevent recurring Clostridioides difficile infection for patients age 18 years and older who are following antibiotic treatment for recurring episodes.
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Is Screening for Atrial Fibrillation Cost Effective?
Self-screening for atrial fibrillation in elderly individuals could lead to lower stroke rates, prevent bleeding-related hospitalizations, and save money.
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COVID-19: Beware Remdesivir Resistance
Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.
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Triglyceride-Lowering Therapy and Cardiovascular Events
Researchers studied pemafibrate vs. placebo in patients with type 2 diabetes, mild-to-moderate triglyceride elevations, and low levels of HDL and well-controlled LDL cholesterol. Despite a 31% reduction in triglyceride levels, there was no improvement in the risk of cardiovascular outcomes over a median follow-up of 3.4 years.
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Is Red Meat Really Unhealthy?
A thorough review of the evidence raises questions about the health risks of eating unprocessed red meat.
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Body Weight Decline in Cognitively Intact Older Adults May Predict Future Cognitive Impairment
Among cognitively intact individuals, those who developed mild cognitive impairment (MCI) recorded faster body mass index (BMI) decline and significantly lower BMI seven years before MCI diagnosis.
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Evaluation and Treatment of Acute Ischemic Stroke
The primary goal of acute stroke care is to salvage as much brain tissue as possible by identifying patients likely to benefit from IV thrombolysis and/or endovascular thrombectomy and delivering treatment safely and promptly.