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The clinical utility of microvolt T-wave alternans (MWTA) testing to detect subtle beat-to-beat oscillations in the electrocardiogram's T-wave amplitude as a non-invasive method for predicting sudden cardiac death remains undetermined.
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Dronedarone is a new antiarrhythmic drug with structural similarities to amiodarone.
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The optimal timing of surgery for asymptomatic severe mitral valve regurgitation (MR) is unclear. Thus, Kang et al from South Korea studied the outcomes of patients treated with early surgery to those treated more conservatively in a prospective observational study.
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Efforts to decrease door-to-balloon time for primary percutaneous intervention (PCI) in an acute ST elevation myocardial infarction (STEMI), may include preferential triage to hospitals expert in primary PCI, partly because of evidence suggesting better outcomes.
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Revascularization, in conjunction with optimal medical therapy, remains a critical component in therapy for patients with obstructive coronary artery disease (CAD).
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Since the risk of gastrointestinal bleeding is increased when clopidogrel is added to aspirin therapy in patients with acute coronary syndromes (ACS), many prescribe proton-pump inhibitors (PPIs) to reduce this risk. However, mechanistic studies suggest that PPIs may reduce the effectiveness of clopidogrel.
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Individualization of therapy with pharmacogenetics; the rate vs rhythm debate; the FDA's Risk Evaluation and Mitigation Strategy; FDA actions.
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The monoclonal antibody, rituximab, appears to benefit patients with myasthenia gravis that is refractory to other modalities.
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When compared with conventional disease-modifying anti-rheumatic drugs (DMARD), tumor necrosis factor (TNF)-Alpha antibody treatment for rheumatoid arthritis (RA) may increase the risk of herpes zoster.