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Role of the Hypothalamus in Migraine and Cluster Headaches
The hypothalamus plays a regulatory role in both migraine and cluster headaches. However, the two headache types have distinctive clinical features, characteristic areas of resting state functional connectivity on magnetic resonance imaging, and different genetic chronobiological associations.
The Hippocratic Oath: Are We Hurting Ourselves and Each Other?
While there are multiple definitions of well-being, it commonly is described as a dynamic and ongoing process involving self-awareness and healthy choices, resulting in a successful and balanced lifestyle. Burnout results from chronic stress, which leads to emotional exhaustion, depersonalization, and decreased feelings of personal accomplishment. Unfortunately, given the rigor of the healthcare profession, healthcare providers often need to remember to consider their emotional well-being while navigating the shift toward an oligopolistic medical industry that perpetuates the cycle by focusing on profit — totaling 18.3% of the gross domestic product.
Doxycycline Demonstrates Protection Against Sexually Transmitted Infections
Common antibiotic could be a key tool to help stem the rising tide of reported cases.
Poor Sleep Patterns Could Raise Stroke Risk
Researchers provide another reason why patients should be resting well every night.
An Oral PCSK9 Inhibitor — Coming Soon?
A Phase IIb study of four doses of MK-0616, an orally administered PCSK9 inhibitor, compared to placebo showed significant reductions in LDL cholesterol levels without any differences in adverse effects over eight weeks.
Cardiovascular Outcomes with Bempedoic Acid, a New Statin Alternative
A trial of bempedoic acid vs. placebo for statin-intolerant patients showed bempedoic acid significantly lowered LDL cholesterol levels and prevented more major adverse cardiovascular events after a median follow-up of 41 months. Although nonserious side effects were numerically higher for those on bempedoic acid, serious adverse events were not significantly different from placebo.
The Best Use of Statins in Patients with Coronary Artery Disease
A randomized, multicenter study of high-intensity statin therapy to a treat-to-target approach in coronary artery disease patients showed no difference in three-year outcomes. These results suggest treating to a target may be more suitable to individual patients compared to blanket high-intensity statin use.
Improving Statin Tolerance in Elderly Patients
In a post-hoc analysis of the RACING trial, researchers found the combination of moderate-intensity statin and ezetimibe therapy vs. high-intensity statin therapy alone in older subjects resulted in similar reductions in cardiovascular events over three years, but fewer adverse effects with the combination therapy.
Clip Found to Be Safe and Effective for Alleviating Tricuspid Regurgitation
In this randomized trial of tricuspid transcatheter edge-to-edge repair, the intervention was found to be safe and effective at alleviating tricuspid regurgitation. Quality of life scores improved with intervention compared with medical therapy, although death and heart failure hospitalization rates were not significantly different.
Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein-ehtl (Altuviiio)
Altuviiio can be prescribed to adults and children with hemophilia A (congenital factor VIII deficiency) for routine prophylaxis to reduce the frequency of bleeding episodes, on-demand treatment and control of bleeding episodes, and perioperative bleeding management.