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Do NSAIDs Cause More Chronic Pain?
Acute inflammation may protect against the development of chronic pain through neutrophil activation. Using nonsteroidal anti-inflammatory drugs may blunt that response and contribute to chronic pain.
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Alzheimer’s Research Funding Receives Boost
The fiscal year 2023 federal budget also includes provisions to strengthen accelerated drug approval and Alzheimer’s public health infrastructure.
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Cerebral Amyloid Angiopathy and Brain Hemorrhage
When comparing the time course of hematoma expansion between deep hematomas and lobar hematomas from cerebral amyloid angiopathy (CAA) and other etiologies, lobar hematomas from CAA show greater expansion and a longer period of risk for hematoma growth compared to deep hematomas.
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Brain Iron Chelation with Deferiprone in Parkinson’s Disease
In a randomized, placebo-controlled treatment trial, deferiprone administered to early, levodopa-naive Parkinson’s disease patients over 36 weeks was associated with worsening of their symptoms, in spite of imaging evidence for reduction of iron in the substantia nigra.
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Body Weight Decline in Cognitively Intact Older Adults May Predict Future Cognitive Impairment
Among cognitively intact individuals, those who develop mild cognitive impairment (MCI) had faster body mass index (BMI) decline and significantly lower BMI seven years before MCI diagnosis. However, after MCI diagnosis, there was no difference in BMI decline between patients who developed dementia and those who did not.
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What Is Oculopharyngodistal Myopathy?
Distal limb myopathies are rare disorders and are difficult to diagnose. Current muscle biopsy technology, coupled with genetic analysis, offers the best hope for an accurate diagnosis of these unusual neuromuscular disorders. Unfortunately, treatments remain elusive.
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Misdiagnosis of Autoimmune Encephalitis
A recent multicenter, retrospective review of 393 adult patients given a diagnosis of autoimmune encephalitis noted that 107 patients (27%) were misdiagnosed and ultimately had other diagnoses confirmed, but after a considerable delay.
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Long-Term Statin Use Associated with Lower Stroke Risk
A cohort of Danish patients who were taking the cholesterol control medication were less likely to experience an intracerebral hemorrhage.
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A Review of Insulin Transition
Diabetes mellitus is a collection of chronic metabolic diseases that occur either as the result of insulin deficiency or insulin resistance. One of the primary goals in diabetes treatment includes lowering blood glucose levels sufficiently to prevent microvascular and macrovascular complications. The type of insulin prescribed depends on multiple factors, and insulins frequently are interchanged. Before choosing or transitioning to an appropriate insulin, consider all social determinants and individualize the treatment regimen as “one size does not fit all.”
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What Will Happen to the Reproductive Healthcare Workforce?
Months after Roe v. Wade was overturned, reproductive healthcare providers and patients are experiencing enormous — and sometimes disastrous — changes. For instance, state abortion bans are expected to affect where OB/GYNs and other reproductive health clinicians choose to study and practice. These bans also will affect how and whether medical students and residents are fully educated in contraceptive care and counseling, abortion care, miscarriage care, ectopic pregnancy treatment, and high-risk pregnancy care.