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Do Antidepressants Increase Risk of Suicide?; Can Viagra Improve Heart
Function?; A Dramatic Increase of Clostridium difficile; FDA Actions
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In a clinical trial conducted in Mexico City, 162 women with systemic lupus erythematosus were randomized to treatment with 1 of 3 contraceptive methods: estrogen-progestin oral contraceptives, oral progestin-only, or a copper IUD. Disease activity remained equally mild and stable over 1 year in all 3 groups.
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The standard approach to adjuvant therapy in women with advanced ovarian cancer is intravenous platinum-based chemotherapy, usually in combination with a taxane. Since the disease is largely characterized by a disseminated intraperitoneal spread pattern, investigators have been interested as whether the disease may respond to therapy administered in the same route.
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In the December Green Journal there was an excellent review by Ken Moise on the current status of umbilical cord blood stem cells. Since this is a topic patients frequently ask about, this month I will depart from the usual alert format to abstract this informative article.
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Patient 1: A healthy 18-year-old woman underwent medical abortion at 47 days gestation and 4 days later was seen in an emergency ward with abdominal cramping. She was afebrile and there was no tenderness on physical examination.
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There have been no new agents approved to treat gout for over 20 years. Because the plasma becomes supersaturated at a uric acid level of 6.0 mg/dL, it is felt that persons with a diathesis for tissue deposition of urate (gouty arthritis, tophi, or both) will optimize benefit by maintaining serum uric acid (SUA) below this level.
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In the autumn of 2001, construction workers in the Siaures Miestalis (Northern Town) section of Vilnius uncovered a mass grave containing several thousand neatly stacked skeletons, most in a fetal position.
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This study from a single diabetic foot clinic in France involved a retrospective chart review of patients who underwent surgical percutaneous bone biopsy with culture for microbiologic diagnosis of osteomyelitis. Patients included for study were those who had not received either local or systemic antibiotics for at least 4 weeks prior to cultures being obtained.
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Since the fda approval of moxifloxacin in December 1991 for the treatment of community-acquired pneumonia, sinusitis, acute bacterial exacerbation of chronic bronchitis, and uncomplicated skin/skin structure infections, its indications for use has been expanded to include the treatment of complicated skin/skin structure infections and complicated intra-abdominal infections.
