Clinical
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The Best Use of Statins in Patients with Coronary Artery Disease
A randomized, multicenter study of high-intensity statin therapy to a treat-to-target approach in coronary artery disease patients showed no difference in three-year outcomes. These results suggest treating to a target may be more suitable to individual patients compared to blanket high-intensity statin use.
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Improving Statin Tolerance in Elderly Patients
In a post-hoc analysis of the RACING trial, researchers found the combination of moderate-intensity statin and ezetimibe therapy vs. high-intensity statin therapy alone in older subjects resulted in similar reductions in cardiovascular events over three years, but fewer adverse effects with the combination therapy.
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Clip Found to Be Safe and Effective for Alleviating Tricuspid Regurgitation
In this randomized trial of tricuspid transcatheter edge-to-edge repair, the intervention was found to be safe and effective at alleviating tricuspid regurgitation. Quality of life scores improved with intervention compared with medical therapy, although death and heart failure hospitalization rates were not significantly different.
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Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein-ehtl (Altuviiio)
Altuviiio can be prescribed to adults and children with hemophilia A (congenital factor VIII deficiency) for routine prophylaxis to reduce the frequency of bleeding episodes, on-demand treatment and control of bleeding episodes, and perioperative bleeding management.
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Identifying High-Risk Cancer Patients Through Appropriate Screening
Less than 20% of average-risk women receive guideline-adherent cervical cancer screening, and guideline-adherent screening was highest for primary HPV testing.
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Effectiveness of Dietary Supplements on Lipid and Inflammatory Biomarkers
In a comparison of rosuvastatin 5 mg/day, six common dietary supplements marketed for improving heart health, and placebo, none reduced high-sensitivity C-reactive protein levels. Only rosuvastatin significantly reduced LDL cholesterol levels compared to placebo.
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COVID Transmission During Air Travel
Despite careful air filtration in flying aircraft, there remains some risk of disease transmission during travel.
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Patients Managing Severe Hypertension Should Avoid Drinking Too Much Coffee
Among patients with severe hypertension, drinking two or more cups of coffee a day was associated with twice the risk of death from cardiovascular disease, while green tea did not increase risk.
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Moderate-Intensity Exercise OK for Statin Users with Muscle Pain
The go-to drug therapy patients use to lower their bad cholesterol levels can cause muscle pain for some, but researchers found moderate exercise would not exacerbate that pain.
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Failure to Report Study Findings in Timely Manner Erodes Public Trust
Further, this can contribute to bias in the scientific knowledge base, limit the ability of future investigators to build on knowledge generated from prior research, and lead to duplication of research efforts and misuse of scarce resources.