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Mammograms: The Cost of Overdiagnosis
In the United States, the costs associated with the management of false-positive mammograms and breast cancer overdiagnosis is estimated to be $4 billion each year.
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Are We Ready to Give Up the Pap Smear?
A review of the ATHENA trial, which evaluated the prevalence of hrHPV in a large cohort of women and evaluated the most sensitive screening strategy.
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Isotretinoin and Contraception: Should iPLEDGE Be Changed?
In this study of female dermatologic patients, knowledge of the typical effectiveness of contraceptive methods increased after viewing a simple information sheet. Given the teratogenicity of isotretinoin, expanding the use of highly effective contraceptive methods among women of child-bearing potential using this medication is essential.
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Wide Tachycardia in a Patient with Chest Pain
The 12-lead ECG and accompanying long lead II rhythm strip in the Figure was obtained from a 70-year-old woman with chest pain. She was hemodynamically stable at the time this ECG was recorded. What is the rhythm? -
Clinical Briefs
Accumulation of briefs: Consequences of NSAID Use in Patients Receiving Post-MI Antithrombotic Prophylaxis, Psoriasis Is Associated with Insulin Resistance, and Difficult Questions About Testosterone and Mortality
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Steroids for Severe Community-Acquired Pneumonia: More Evidence or More Uncertainty?
Community-acquired pneumonia (CAP) is the leading cause of mortality from infection in industrialized countries, and treatment failure occurs in 10-20% of cases despite appropriate antibiotic therapy. Thus, effective treatment strategies that reduce the burden of CAP would have a major impact on public health. Several previous studies that investigated the role of corticosteroids in CAP produced mixed results. Torres and colleagues hypothesized that corticosteroids modulate the immune response in severe CAP, thereby decreasing treatment failure.
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Effects of Lifestyle Modifications on the Coronary and Carotid Atherosclerotic Burden
A look at how lifestyle changes, including dietary modifications and regular exercise, impact therapy for atherosclerotic cardiovascular disease.
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Diet Sodas: Are They Really Diet?
Over the past several decades, concerns about increased sugar consumption has led some experts to recommend the use of non-nutritive sweeteners (NNSs).1
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No Link Between MMR and Autism
In this issue: Prevention of Type 1 Diabetes in Children; Early Initiation of HPV Vaccine; Effects of Antibiotic Exposure Early in Life; ED-initiated Buprenorphine for Opioid-dependent Patients; and FDA Actions.
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Roflumilast for Acute Exacerbations in COPD
Acute exacerbations of COPD are potentially highly consequential: in-hospital mortality is approximately 10%, and up to 25% of patients admitted to the ICU die.