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Travel Medicine: News You Can Use
In May, 1,296 travel medicine specialists gathered in Quebec City, Canada, for the 14th biannual conference of the International Society of Travel Medicine. Several of the topics discussed are practically relevant to readers of Infectious Disease Alert, so we offer this Top 10 list of news items.
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Infectious Diseases Grand Rounds — Stanford University
CASE: A 55-year-old male with an atypical cause of osteo-articular infection
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Measles-induced Immunomodulation and Impact on Childhood Mortality
Population-level studies in high-resource countries demonstrated that fluctuations in childhood mortality from all infectious diseases are strongly associated with measles infection. The effect is likely attributable to generalized immunomodulation that follows measles infection, with a duration of two to three years.
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Antibiotics for Intraabdominal Infections: Less Is More
A multi-center, randomized trial comparing patients with complicated intraabdominal infections found no difference in outcomes between those who received 4 days of antibiotic therapy vs. 8 days after adequate source control.
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Duration of Antibiotic Treatment for Vertebral Osteomyelitis
Three hundred fifty-nine patients with pyogenic vertebral osteomyelitis were randomized to 6 weeks vs. 12 weeks of antibiotic treatment in an open-label controlled trial. Six weeks of antibiotics was found to be not inferior to 12 weeks of treatment.
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Folate Supplements and Primary Stroke Prevention
The study has significant implications for stroke prevention across the globe by utilizing a safe and inexpensive folate supplementation or fortification strategy.
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Long-Term Weight Loss Rivals Medications and Ablation for AF Rhythm Control
Weight loss alone compares quite favorably with other strategies for AF rhythm control.
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New Insight into Anthracycline Cardiotoxicity
Cardiotoxicity occurs early on, and with prompt initiation of standard medical therapy for systolic heart failure, most patients can usually recover LV function.
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Antiplatelet Therapy After TAVR: Where are the Data?
Dual antiplatelet therapy is associated with higher rates of bleeding compared with aspirin alone, but evidence supporting its efficacy post-transcatheter aortic valve replacement is sparse.
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Is It Time to Purge Full-Strength Aspirin from the Outpatient Armamentarium?
There's further evidence of a lack of benefit to high-dose maintenance aspirin, along with a suggestion of harm.