Clinical
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Mammography and the Overdiagnosis of Breast Cancer: What to Do?
A new study reports that the incidence of breast cancer is higher in counties with high rates of mammography screening, but screening is not associated with a decrease in breast-cancer deaths. The decision of whether and how often to perform mammography requires a discussion of the potential consequences of both true positive and false positive screening tests.
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Vulvar Lichen Sclerosus: How Long Should Women Be Treated?
In this prospective cohort study, women with vulvar lichen sclerosus who were compliant with preventive topical corticosteroids were significantly less likely to develop vulvar intraepithelial neoplasia and squamous cell carcinoma than women who were partially compliant with therapy.
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Reviewing VTE Risk with Newer Progestins — Journal Watch, We Think You're Wrong
We disagree with a review of a new study on the elevated risk of VTE in users of combined pills. Our abstract & commentary digs deep.
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Measuring the Quality of Care Provided to Women with Pelvic Organ Prolapse
Quality can be measured for women with pelvic organ prolapse, and in many areas the care of women with this condition can be improved.
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Cryptogenic Stroke and Atrial Fibrillation
In large prospective databases of ischemic stroke, cryptogenic stroke occurs in as many as 30% of all ischemic stroke patients. Many of these patients have the characteristics of cardioembolic stroke, and there has always been a strong suspicion that some of these patients have atrial fibrillation.
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Antibiotics for Intra-abdominal Infections: Less Is More
Complicated intra-abdominal infections cause significant morbidity and mortality, especially in the elderly. Often these infections are treated with antibiotics until all the signs and symptoms of the systemic inflammatory response syndrome resolve, typically for 7 to 14 days.
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Duration of Antibiotic Treatment for Vertebral Osteomyelitis
Three hundred fifty-nine patients with pyogenic vertebral osteomyelitis were randomized to 6 weeks vs. 12 weeks of antibiotic treatment in an open-label controlled trial. Six weeks of antibiotics was found to be not inferior to 12 weeks of treatment.
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VTE Occurs Frequently in Patients with Sepsis
The purpose of this multicenter study was to prospectively determine the incidence of VTE among ICU patients with sepsis and septic shock, and to identify independent risk factors for VTE in these patients.
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Inferior Vena Cava Filters and Recurrent Pulmonary Embolism
Placement of retrievable inferior vena cava filters in individuals with concurrent DVT does not reduce the risk of recurrent pulmonary embolism.
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Clinical Briefs
Distinguishing the major differences within the class of beta-blockers; delay in the diagnosis of hepatocellular carcinoma; and a closer look at an under-recognized form of orthostatic hypotension.