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Incidental Cerebral Microbleeds and Cerebral Blood Flow in Elderly Individuals
Cerebral microbleeds in non-demented elderly people are associated with a global reduction in cerebral blood flow and a high prevalence of beta-amyloid deposition in the brain.
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Idarucizumab: A Promising New Drug that Reverses the Anticoagulant Effects of Dabigatran
A recent study found that idarucizumab rapidly reverses the effects of dabigatran and is likely to have important clinical benefits for patients with intracerebral hemorrhage and other disease processes in which reversal of anticoagulation is important.
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Diverticulitis: Evaluation and Management
Diverticulitis is a result of acute inflammation of colonic diverticulum. Acute diverticulitis is placing an increasing burden on health care resources as the incidence, prevalence, and hospital admission rate is rapidly increasing. Its timely diagnosis and treatment are essential to help improve outcomes for patients. The ability to recognize complicated versus uncomplicated diverticulitis can aid in expedited care and resource allocation to prevent repeat radiation exposure through radiological imaging of these patients who present with uncomplicated diverticulitis.
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Environmental Influences on Male Reproductive Function
This special feature is intended to provide readers with information needed about the potential impact of the environment and lifestyle on male reproductive function so that they can better take histories and counsel couples presenting with questions about infertility.
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When Do Combined Oral Contraceptives Start Working After Ulipristal Acetate Emergency Contraception?
In this randomized, controlled trial of the effects of combined oral contraceptives on ovarian activity after taking ulipristal acetate, investigators found that some women needed up to 14 days to achieve ovarian quiescence. Therefore, abstinence or backup contraception should be used during that time.
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Good News for a Change: No Association of Hormonal Replacement Therapy with Breast Cancer Before Age 50
Using data from the Two Sister Study, investigators found no association of past combined hormone replacement therapy with young-onset (before age 50) breast cancer, and a protective effect with estrogen-only therapy.
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Handheld Ultrasound for Assessing Fetal Size
A recent study has shown abdominal circumference assessments with a portable handheld ultrasound machine to be superior to standard fundal height measurements in the prediction of small for gestational age and large for gestational age fetuses in utero and infants at birth.
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Clinical Briefs
In this section: Reconsidering the value of oral nutritional supplementation in patients admitted for COPD; recognizing a relationship between asthma and obesity; and weighing the benefits of sound stimulation in Alzheimer's patients.
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Eluxadoline Tablets (Viberzi) and Rifaximin (Xifaxan) Tablets
Both drugs appear to provide modest benefit in irritable bowel syndrome with diarrhea.
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Statin Use and Cognitive Effects: Not a Brain Drain
A meta-analysis of data from more than 28,000 patients enrolled in 18 randomized, placebo-controlled trials of statin therapy failed to show a causal relationship between treatment and adverse neurocognitive effects for patients with and without cognitive impairment.