Clinical
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Cerebrospinal Fluid Tau and Amyloid-ß1-42 in Patients with Dementia
In patients with clinically diagnosed dementia, the CSF biomarker profile of low CSF amyloid-ß1-42, high total tau, and high phosphorylated tau was seen in the majority of patients with clinically diagnosed Alzheimer’s disease. Substantial proportions of patients with non-Alzheimer’s dementia were also found to have the Alzheimer’s disease pathological profile. The value of CSF biomarker measurements in clinical practice is uncertain.
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Vitamin D and Diabetic Neuropathy
Vitamin D deficiency may exacerbate the clinical manifestations of diabetic neuropathy, and supplementation with vitamin D3 may be beneficial.
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The Expanding Role of Tau in Neurodegeneration: New Insights from Huntington’s Disease
Although Huntington’s disease is due to a triplet repeat expansion in the huntingtin gene, this study demonstrates abnormally phosphorylated tau pathology in Huntington’s disease brain tissue.
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Small Fiber Neuropathy in Critical Illness
The spectrum of critical illness polyneuropathy may include painful, small-fiber degeneration that can be readily diagnosed by punch skin-biopsy.
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Fibromyalgia and Other Soft Tissue Pain Syndromes
MONOGRAPH: Sometimes it's helpful to ask the patient, “Do you have anywhere on your body that doesn’t hurt?”
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Spice is Nice
The habitual consumption of spicy foods is associated with reduced mortality independent of other risk factors for death.
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N-acetylcysteine as Adjunctive Therapy for Therapy-resistant Tobacco Use Disorder
Tobacco cessation programs have variable success rates and often employ the use of multiple strategies, including behavioral counseling and pharmaceutical treatments. This study investigates the use of N-acetylcysteine in combination with group behavioral therapy as a treatment for tobacco use disorder resistant to first-line smoking cessation treatments.
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Omega-3s for the AREDS2 Cohort Are Not Beneficial for Preventing Cognitive Decline
A sub-analysis of the AREDS2 randomized, controlled trial that involved supplemental omega-3 fatty acids failed to find benefit on cognitive function over 5 years.
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Integrative Therapies for Type 2 Diabetes Mellitus: Botanical Supplements
This review will focus exclusively on the role of botanicals for treating type 2 diabetes mellitus. Only recently have rigorous research methods been applied to the study of botanical remedies.
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Infectious Disease Alert Updates
Coccidioidomycosis: Is the “Zone” Growing?
Cocci as a Cause of Marine Mammal Mortality
Initial and Much Too Subtle Ebola Virus Infection