Clinical
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Acetaminophen for Fever in the ICU
Seven hundred ICU patients with fever and known or suspected infection were randomly assigned to receive acetaminophen 1 g IV or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial therapy, or death. Early administration of acetaminophen did not affect number of ICU-free days.
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Dual Combination ART with Cabotegravir and Rilpivirine Is Effective for Maintaining HIV Virological Suppression
Results of the phase 2 LATTE study show that after 24 weeks of induction triple therapy, maintenance therapy with cabotegravir (a long-acting dolutegravir analogue) and rilpivirine led to virological suppression in 82% of patients, compared to 71% who received efavirenz plus two NRTIs.
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Cutaneous Leishmaniasis in Syrian Refugees
Cutaneous leishmaniasis is spreading as refugees move from Syria through Turkey into Europe and throughout the world. Aware clinicians can consider diagnostic testing when facing unusual skin lesions in refugees.
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Xenotourism: Live Cell Therapy, Maybe Not So Therapeutic
ABSTRACT & COMMENTARY: Beware injection with sheep fetal cells.
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Chronic Obstructive Pulmonary Disease: Update
Over the past decade, this definition of COPD has changed dramatically, as has the characterization and treatment of individuals with COPD. Multiple new therapies alter the course of this disease, reduce exacerbations, improve quality of life, and increase survival; previous nihilistic approaches to the management of COPD have been replaced by directed and effective pharmacologic and nonpharmacologic therapies. This update will review current approaches to the diagnosis and management of COPD and present the most recent evidence for the classification of COPD phenotypes and the implications of these categories for COPD treatment and prognosis.
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Every 5-minute Delay in Performing Endovascular Reperfusion Results in 1 out of 100 Patients Having a Worse Disability Outcome
Every 5-minute delay in performing endovascular reperfusion results in 1 out of 100 patients having a worse disability outcome.
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Treatment for Ulnar Neuropathy at the Elbow
In a randomized treatment trial of steroid injection into the cubital tunnel for ulnar neuropathy, there was no difference in outcome compared to placebo.
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Botulinum Toxin and Treatment of Spasticity
AbobotulinumtoxinA is effective at reducing spasticity and reducing disability in patients with upper limb spasticity due to stroke or traumatic brain injury.
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Lower Risk of Parkinson’s Disease After Vagotomy: Implications for Spread of Pathology
Truncal vagotomy was associated with a reduced risk for Parkinson’s disease with a hazard ratio of 0.58 for those with more than 20 years’ follow-up. This suggests the vagus nerve as a possible route of entry into the central nervous system for this neurodegenerative process.
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Potential Imaging Biomarkers of SUDEP: Can We Predict Sudden Death in Epilepsy?
The authors retrospectively conducted a voxel-based analysis of T1 MRI scans to compare gray matter volumes in 12 cases of sudden unexpected death in epilepsy (SUDEP) acquired at a median of 2 years before death with patients at high or low risk for SUDEP and with healthy controls, and demonstrated significant anatomical differences between the groups.