Clinical
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Daclatasvir Tablets (Daklinza)
Daclatasvir plus sofosbuvir is the first interferon and ribavirin-free regimen for the treatment of HCV genotype 3.
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Delay in Performing Endovascular Reperfusion Results in Worse Disability Outcomes
For every 15-minute acceleration in the time to reperfusion, 34 per 1000 patients treated will have improved disability outcomes.
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Botulinum Toxin and Treatment of Spasticity
AbobotulinumtoxinA is effective at reducing spasticity and reducing disability in patients with upper limb spasticity due to stroke or traumatic brain injury.
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The Mediterranean Diet Plus Extra Virgin Olive Oil May Improve or Maintain Cognitive Function in Mature Adults
In an older population, a Mediterranean diet supplemented with olive oil or nuts is associated with improved cognitive function compared with controls on a low-fat diet.
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Sleep Patterns Predict Diabetes Risk
Work schedules that interfered with sleep increased the risk of type 2 diabetes.
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FDA Actions
FDA approves reversal agents, signs off on schizophrenia drug, warns of liver damage associated with hepatitis C treatment, green lights hyperkalemia treatment, and approves the first oncolytic virus for the treatment of melanoma.
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Rethinking Calcium Supplementation
Increasing calcium intake from dietary sources or supplements produces small, non-progressive increases in bone mineral density, which are unlikely to make a clinically significant reduction in fracture.
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Infectious Disease Alert Updates
Meningitis Diagnostics
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Anti-parasitic Therapy of Chronic Chagas’ Cardiomyopathy
Two thousand eight hundred fifty-four patients with Chagas’ cardiomyopathy were randomized to benznidazole or placebo, were treated for up to 80 days, and were followed for a mean of 5.4 years. Trypanocidal treatment with benznidazole reduced serum parasite detection but did not reduce clinical cardiac deterioration.
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Oritavancin: Formulary Considerations
Oritavancin is a lipoglycopeptide bactericidal antibiotic for intravenous administration with activity against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus.