Clinical
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Ceftazidime-avibactam — Formulary Considerations
Ceftazidime-avibactam is a new beta-lactam/beta-lactamase inhibitor combination approved for the treatment of complicated intra-abdominal infections in combination with metronidazole, and complicated urinary tract infections, including pyelonephritis in patients with limited alternative treatment options.
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Idarucizumab Injection (Praxbind)
The FDA has approved the first reversal agent for a direct oral anticoagulant. Idarucizumab is a humanized monoclonal antibody fragment derived from an IgG1 isotype molecule. -
Optimal Beta-blocker Dose Post-MI
Beta-blocker therapy after acute myocardial infarction was retired as a hospital performance measure because its almost universal acceptance removed its discriminating value. However, it is well known that clinically used doses are significantly lower than those achieved in the randomized trials, establishing their mortality-reducing benefits.
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Can We Safely Discharge Patients on the Weekend?
ABSTRACT & COMMENTARY: The link between weekend discharge and 30- and 90-day readmission rates.
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Evaluation of Syncope
MONOGRAPH: Here's how to determine the appropriate treatment and disposition outcomes in the most time- and cost-effective manner.
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Small Vessel Disease Often Accompanies Large Vessel Intracranial Atherosclerosis
The SAMMPRIS trial investigated the consequences of medical vs endovascular therapy for the treatment of symptomatic intracranial atherosclerosis, and points out the high prevalence of coexisting small vessel disease with large vessel atherosclerosis.
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Loss of Consciousness at Onset of Aneurysmal SAH: Poor Prognosis
Loss of consciousness at onset of Aneurysmal subarachnoid hemorrhage is an indicator of early brain injury and predicts poor functional outcome or death at 12 months.
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Left Atrial Dysfunction Without Fibrillation Increases Stroke Risk
Lleft atrial abnormalities that do not necessarily result in atrial fibrillation, may also increase the risk of stroke and should be investigated and searched for in patients with ischemic stroke consistent with cardiogenic embolism.
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Vision Problems After Ischemic Stroke: Effects on Quality of Life
Visual impairments are common in stroke survivors and should prompt a careful ophthalmologic evaluation, since many of the problems are ocular and not neurological.
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Acetylcholine Receptor Antibody Testing in Ocular Myasthenia Gravis
More than two-thirds of patients with ocular myasthenia will have a positive antibody test, and a high level may predict progression to generalized disease.