Clinical
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Optimal Beta-blocker Dose Post-MI
Investigators from the Outcome of Beta-blocker Therapy After Myocardial Infarction (OBTAIN) study hypothesized that the higher the dose of beta-blocker the lower the mortality.
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Metformin and Colorectal Cancer Risk
In a retrospective cohort study of patients with type 2 diabetes who had ≥ 1 adenoma detected at baseline colonoscopy and a repeat colonoscopy 1-10 years later, metformin use lowered the risk of subsequent adenomas after polypectomy.
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Cardiovascular Events Associated with Masked Hypertension and White-coat Hypertension
Analysis from the Dallas Heart Study consisting of 3027 adults revealed that both white-coat hypertension and masked hypertension were independently associated with increased cardiovascular events, and, therefore, home blood pressure monitoring is recommended for U.S. adults, whether symptomatic or asymptomatic.
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Is There a Link Between Miscarriage and Future Cardiovascular Disease?
In this Scottish retrospective cohort study of 60,000 women, two or more miscarriages were found to increase the risk of future ischemic heart disease by two- to three-fold.
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Does a History of D&C Increase the Risk of Premature Delivery?
In a meta-analysis, a history of dilation and curettage for management of miscarriage or termination of pregnancy was associated with an increased risk of preterm birth in a subsequent pregnancy but the association is weak and most likely explained by confounding.
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Low-dose Aspirin and Preeclampsia
A study comparing outcomes before and after offering low-dose aspirin to patients who were deemed to be high risk by a first trimester protocol showed a decrease in preterm birth prior to 34 weeks and a decrease in early-onset preeclampsia.
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Menopausal Hormone Therapy: Useful and Indicated for Vasomotor Symptoms
The benefits may exceed the risks for most women within 10 years of menopause.
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FDA Actions
In this section: The FDA may soon recommend against using codeine for pain and cough in children underage children; vitamin D supplementation may not prevent elderly falls after all; agency approves insulin glargine for the treatment of diabetes; and mepolizumab for maintenance treatment of asthma when used with other asthma medications receives approval.
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Comparing Type 2 Diabetes Drug Therapies
A new evidence review compares the weekly glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes.
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Report: Opioid Overdose Deaths Up 200% Since 2000
Death by prescription drugs is out of control.