Clinical
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High Blood Pressure: How Low Should We Go? SPRINT and a New Meta-analysis
A recent meta-analysis supports the benefit of targeting lower blood pressure levels.
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FDA Actions
The FDA has approved a new fixed-dose combination oral, once-daily pill to treat hepatitis C genotypes 1 and 4.
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Time to Limit Proton Pump Inhibitors?
A new study suggests the commonly used drugs may be associated with chronic kidney disease.
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Promising Treatment Not Widely Available
Among adults with recurrent or refractory Clostridium difficile infection, the use of frozen compared with fresh fecal microbiota transplantation did not result in worse proportion of clinical resolution of diarrhea.
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New Recommendations for Bisphosphonate Therapy
For women who are not at high risk after 3-5 years of bisphosphonate therapy, a drug holiday of 2-3 years may be considered.
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Study: No Link Between Dementia, Benzodiazepine Use
New research upends previous beliefs.
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Updated Antithrombotic Therapy Guidelines Released
The guideline contains some significant changes from the previous CHEST guidelines.
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Smoking and Low Back Pain
Yet another reason to encourage smoking cessation.
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What’s the Deal with Grapefruit Juice?
Research suggests the combination of grapefruit juice with simvastatin would increase simvastatin blood levels, but at the same time would possibly reduce cardiovascular event levels to a degree that would counterbalance any increased risk of rhabdomyolysis.
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Ambulatory BP for All
Considering that it could save a patient years of unnecessary treatment, we should follow the advice the British adopted long ago: ambulatory blood pressure monitoring for all initially diagnosed hypertensives to confirm the diagnosis.