Clinical
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Nitrate Therapy Shows Possible Harm in Heart Failure with Preserved Ejection Fraction
In heart failure with preserved ejection fraction, the use of isosorbide mononitrate was associated with a nonsignificant decrease in physical activity level, and no improvement in symptoms or quality of life.
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The Portal of Bacterial Entry in Infective Endocarditis
ABSTRACT & COMMENTARY: A comprehensive, systematic search for the portal of bacterial entry in infective endocarditis is frequently successful.
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By Using In Vitro Fertilization, Pregnancy Rates Can Approach Those in Fertile Women
Cumulative live-birth rates were more than 65% after the sixth cycle of in vitro fertilization.
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Use of CNMs and Hospitalists
A study assessing the effects of instituting a model of certified nurse midwife with MD laborist backup on a private patient population showed a decrease in cesarean section rate and an increase in vaginal birth after cesarean delivery rate without any change in combined neonatal outcome.
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Fluconazole Use During Pregnancy
In this large cohort study from Denmark, use of oral fluconazole during pregnancy was associated with a slightly increased risk of spontaneous abortion and no increased risk of stillbirth.
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2016 USPSTF Update: Recommendations for and Effectiveness of Screening Mammography
The U.S. Preventive Services Task Force recently released updates to the 2009 recommendations on breast cancer screening. Additional studies published since the last review strengthen the conclusion that mammography screening results in a reduction in the risk of death from breast cancer.
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Clinical Briefs
In this section: another reason to take vitamin D supplements; polishing physical exam skills; and comparing the relationship between uric acid, fructose, and hypertension.
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Elbasvir and Grazoprevir Tablets (Zepatier)
The FDA has approved another oral interferon-free regimen for the treatment of chronic hepatitis C (HCV) genotypes 1 and 4.
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Should Postmenopausal Women Be Encouraged to Take Calcium?
A systematic review of randomized, controlled trials of calcium supplementation found only small non-progressive increases in bone mineral density. This supports the clinical conclusion that supplementation alone is insufficient to prevent fracture risk.
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Association of Coffee Consumption with Total and Cause-specific Mortality
Regular consumption of both caffeinated and decaffeinated coffee were found to be inversely associated with risk of total mortality and mortality attributed to cardiovascular disease and neurologic diseases.