Clinical
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Improving Statin Tolerance in Elderly Patients
In a post-hoc analysis of the RACING trial, researchers found the combination of moderate-intensity statin and ezetimibe therapy vs. high-intensity statin therapy alone in older subjects resulted in similar reductions in cardiovascular events over three years, but fewer adverse effects with the combination therapy.
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The Best Use of Statins in Patients with Coronary Artery Disease
A randomized, multicenter study of high-intensity statin therapy to a treat-to-target approach in coronary artery disease patients showed no difference in three-year outcomes. These results suggest treating to a target may be more suitable to individual patients compared to blanket high-intensity statin use.
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Cardiovascular Outcomes with Bempedoic Acid, a New Statin Alternative
A trial of bempedoic acid vs. placebo for statin-intolerant patients showed bempedoic acid significantly lowered LDL cholesterol levels and prevented more major adverse cardiovascular events after a median follow-up of 41 months. Although nonserious side effects were numerically higher for those on bempedoic acid, serious adverse events were not significantly different from placebo.
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An Oral PCSK9 Inhibitor — Coming Soon?
A Phase IIb study of four doses of MK-0616, an orally administered PCSK9 inhibitor, compared to placebo showed significant reductions in LDL cholesterol levels without any differences in adverse effects over eight weeks.
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Poor Sleep Patterns Could Raise Stroke Risk
Researchers provide another reason why patients should be resting well every night.
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Insulin Resistance at the Blood-Brain Barrier in Alzheimer’s Disease
Alterations in cerebrovascular insulin receptor isoform levels were associated with Alzheimer’s disease pathology and caused deficits in insulin signaling at the level of the blood-brain barrier.
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Multivitamin-Mineral Supplementation vs. Cocoa Extract for Cognition
Researchers followed participants for three years and determined daily cocoa supplement use was not associated with cognitive enhancement in older adults, whereas a multivitamin supplement was associated with significant cognitive benefits.
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Zavegepant Nasal Spray (Zavzpret)
Zavegepant can be prescribed to treat migraine, with or without aura, in adults.
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Double BBB, or Complete AV Block?
The ECG in the figure is from a woman who complained she had been experiencing chest pain for several days. What is the rhythm? Is there complete AV block?
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Failure to Report Study Findings in Timely Manner Erodes Public Trust
Further, this can contribute to bias in the scientific knowledge base, limit the ability of future investigators to build on knowledge generated from prior research, and lead to duplication of research efforts and misuse of scarce resources.