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Low Back Pain Best Prevented with Exercise and Education
In a meta-analysis of studies on preventing low back pain, researchers found a combination of exercise and education were the most likely interventions to prevent recurrence of this potentially debilitating condition.
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Can Chemotherapy Damage Heart Valves?
Long-term lymphoma survivors were noted to experience valvular regurgitation out of proportion to reductions in left ventricular function and degenerative valve stenosis. The most evidence appeared in those who received radiation therapy in addition to chemotherapy.
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Postoperative Atrial Fibrillation Management — You Can’t Go Wrong
Rate control and rhythm control strategies for cardiac surgery patients with postoperative atrial fibrillation lead to similar hospital durations, similar complication rates, and similar very low rates of atrial fibrillation at 60-day follow-up.
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Can CABG Really Improve Left Ventricular Function?
In implantable cardioverter defibrillator candidates with an ejection fraction < 35% who underwent coronary artery bypass graft surgery, mean ejection fraction improved significantly, especially in those with baseline ejection fraction between 25-35%, obviating the need for an implantable cardioverter defibrillator in 58%.
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CABG Improves Long-term Survival in Severe Left Ventricular Dysfunction
In patients with coronary artery disease, heart failure, and left ventricular ejection fraction < 35%, coronary artery bypass grafting plus medical therapy was associated with improved survival compared to medical therapy alone.
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TAVR in Intermediate-risk Patients: How Low Can We Go?
Transcatheter and surgical aortic valve replacement in an intermediate-risk population have similar rates of death and disabling stroke at two years.
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Meningitis Update
MONOGRAPH: Meningitis is inflammation of the meninges lining the brain that if allowed to progress ultimately leads to increased intracranial pressure.
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Clinical Briefs
In this section: examining autoimmune disorders associated with vitiligo; moderate alcohol consumption is not associated with reduced all-cause mortality; and rethinking the American diet.
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Ixekizumab Injection (Taltz)
Ixekizumab is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
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Outcome of PCSK9 Inhibitor-treated Patients
In a meta-analysis of 17 studies, proprotein convertase subtilisin-kexin type 9 serine protease inhibitors markedly reduced low-density lipoprotein cholesterol levels and all-cause mortality, but was associated with a significant increase in neurocognitive adverse events.