Clinical
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Rivaroxaban in the Real World
A large Phase IV registry study shows that rivaroxaban is associated with a very low incidence of major bleeding, death, or stroke. Also, adherence to therapy was much higher than observed in other studies with vitamin K antagonists.
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New Analysis of COGENT Data Supports Proton Pump Inhibitor Benefit
It shows comparable risks of gastrointestinal and cardiovascular events between low- and high-dose aspirin.
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Pediatric Seizures
Although benzodiazepines remain the first-line therapy, awareness of next steps in therapy is necessary.
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In Memoriam
On May 4, 2016, Dan Mishell, MD, passed away at home surrounded by family.
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Vulvar Squamous Intraepithelial Lesions
The International Society for the Study of Vulvovaginal Disease adapted Lower Anogenital Squamous Terminology to the specifics of the vulva and released the 2015 terminology. Vulvar Low-grade squamous intraepithelial lesion is benign and includes HPV effect and flat condyloma. Vulvarhigh-grade squamous intraepithelial lesion is the usual HPV-associated type of high-grade vulvar intraepithelial neoplasia and the non-HPV-associated type is labeled differentiated-type vulvar intraepithelial neoplasia.
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Colpocleisis: Body Image, Satisfaction, and Regret at 24 Week
Colpocleisis is an effective surgical treatment for pelvic organ prolapse. Women report high satisfaction and low regret.
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Pessaries in Patients with Short Cervices
The largest multicenter, randomized, controlled trial so far has found no significant benefit of pessaries to prevent preterm birth or to decrease neonatal morbidity in patients with short cervices.
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Early Initiation of Postmenopausal Estrogen Therapy
Women randomized to oral estradiol therapy showed less progression of subclinical atherosclerosis than those who received placebo.
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Clinical Briefs
In this section: watching carefully for suicide risk; tackling chronic cough; and a new treatment for Peyronie's disease.
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Reslizumab Injection (Cinqair)
Reslizumab is indicated for add-on maintenance treatment of adult patients with severe asthma with eosinophilic phenotype.