Clinical
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Foreign Bodies of the Head and Neck
MONOGRAPH: Diagnosing and managing ear, nose, and throat foreign bodies with discussion separated by location.
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Endocrine-disrupting Chemicals and Female Reproductive Disorders
The endocrine-disrupting chemicals diphenyl-dichloroethene and phthalates appear to contribute substantially to the incidence of the most common reproductive disorders in women, endometriosis and fibroids, and lead to total costs of 1.5 billion euros in the European Union.
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Still Highly Effective: LNG IUS 52 mg at 7 Years
Data from a large randomized study conducted by the World Health Organization demonstrate that pregnancy rates do not increase after year five, and support the continued use of the levonorgestrel intrauterine system 52 mg for contraception through seven years.
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Infection Risk with Same-day Testing and IUD Insertion
In this prospective trial of same-day chlamydia/gonorrhea testing with intrauterine device insertion among 1,714 women, the risk of subsequent pelvic infection was extremely low (0.2%) over two years of follow-up.
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Prolonged Second Stage of Labor
A recent randomized clinical trial has shown that using a more liberal threshold for second stage labors in nulliparous patients with and without epidural can result in a major decrease in the need for cesarean sections.
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FDA Actions
In this section: FDA approves a subdermal buprenorphine implant for maintenance treatment of opioid dependence; warns health professionals against using ketoconazole for the treatment of skin and nail fungal infection; investigates a possible link between canagliflozin and an increase in leg and foot amputations; advises against using fluoroquinolones for common infections; and green lights daclizumab for the treatment of relapsing multiple sclerosis.
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Research: Using Generic Drugs Could Lead to Billions in Savings
If therapeutic substitution of a generic within the same class had been used instead of the branded equivalent, $73 billion could have been saved, including nearly $25 billion in out-of-pocket expenditures for patients.
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Why is This Young Athlete’s ECG Abnormal?
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Clinical Briefs
In this section: glucose variability in type 2 diabetes; bariatric surgery improves pain and function; and two thumbs down for COPD screening.
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Pimavanserin Tablets (Nuplazid)
Pimavanserin is indicated for the treatment of hallucination and delusions associated with Parkinson's disease psychosis.