Clinical
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Management of Mixed Aortic Valve Disease
Asymptomatic patients suffering from moderate aortic stenosis and regurgitation with preserved left ventricular function have the same prognosis as asymptomatic patients with severe aortic stenosis and normal left ventricular function and should be followed closely for the development of symptoms.
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Predictive Accuracy of the New Risk Equation
An evaluation of the predictive accuracy of the new pooled Cohort Risk Equation in > 300,000 subjects without heart disease or diabetes and a low-density lipoprotein cholesterol level between 70-189 mg/dL followed for five years showed that the new equation markedly overestimated the observed risk of cardiovascular events.
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Arterial Ischemic Stroke Prevention and Risk Factor Management
MONOGRAPH: Here is the best evidence-based practice for stroke diagnosis, prevention, and risk factor management.
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Promising Results for Treating Glioblastoma
New data opens door to important treatment previously unavailable to certain patients.
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Clinical Briefs
In this section: Might a pharmacologic agent that improves insulin resistance be effective in secondary prevention of CV events?; subclinical thyroid disease status associated with mortality in elders; and is there an infectious disease that causes pathological aggression?
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Buprenorphine Implant for Subdermal Administration (Probuphine)
The FDA has approved the first buprenorphine implant for the treatment of opioid dependence.
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Optimal Antiplatelet Therapy for Secondary Prevention of Ischemic Stroke
Patients presenting with acute ischemic stroke often take aspirin on a regular basis for prevention of cardiovascular disease. The optimal antiplatelet therapy for secondary prevention has been uncertain in this setting.
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Prognostic Value of Coronary Calcium on Standard Chest CT Scans
Coronary calcium scan on standard CT scans performed for other indications is of equivalent prognostic value to that seen on ECG-gated coronary studies and should be included in radiology test reports.
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Does Dysbiosis Cause Multiple Sclerosis?
Increasing evidence suggests that dysbiosis, a disorder in the gut microbiome, leads to autoimmune diseases, including multiple sclerosis.
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All You Need Is Love, But a Little Chocolate May Benefit, Too
Chocolate consumption may improve liver enzymes and protect against insulin resistance.