Clinical
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Structural and Functional Imaging ‘Phenotypes’ in Refractory Temporal Lobe Epilepsy Patients
Using high-resolution 3-T magnetic resonance imaging, temporal lobe epilepsy-hippocampal sclerosis showed significant preoperative ipsilateral volume loss, T2 hyperintensity, and mean diffusivity increases across all subfields, with the greatest effects seen anteriorly. However, temporal lobe epilepsy-gliosis showed increased volume in the dentate gyrus bilaterally, and more focal and subtle increases in T2 intensity and mean diffusivity.
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What is the End Game in Creutzfeldt-Jakob Disease Progression?
Cerebellar and psychiatric symptoms at diagnosis of Creutzfeldt-Jakob disease may portend a higher risk for more rapid development of akinetic mutism.
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For Migraine Pain, Green Light May Give Relief
Migraine-related photophobia appears to originate in cone-driven retinal pathways and is then mediated by thalamic neurons. Green light causes less stimulation than other colors.
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Guillain-Barré Syndrome in the Elderly
Guillain-Barré syndrome in the very old (> 80 years of age) results in more severe disease with poorer recovery.
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HPV Vaccines: Why Are We Failing to Vaccinate so Many of Our Adolescents?
Given that this cancer is such a world health problem and the cost of screening is large and unreliable, HPV vaccines should substantially reduce the incidence and cost of both screening for and treating hrHPV-related diseases.
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What Is the Best Way to Perform a Paracervical Block?
ABSTRACT & COMMENTARY: A randomized, controlled trial of first-trimester suction D&C procedures.
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Factor V Leiden Mutation and Combined Hormonal Contraception? Is Thrombosis Risk Acceptable?
A meta-analysis of cohort studies supports that women with mild thrombophilias like heterozygote Factor V Leiden mutation can use combined hormonal contraception if other reliable methods are not acceptable.
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Preterm Premature Rupture of Membranes: When to Deliver?
A recent large multicenter, randomized clinical trial has shown that delivering patients with premature preterm rupture of membranes at 34 weeks, rather than pursuing a watchful waiting approach until 37 weeks, does not afford greater protection against neonatal sepsis.
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FDA Actions
In this section: The FDA approves new chronic hepatitis C treatment, greenlights a treatment course for primary biliary cirrhosis, and strengthens warning about the risk of acute kidney injury in several diabetes medications.
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Patients Need More Education on Opioid Storage, Disposal
Recent survey discovers troubling trends.