Clinical
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Greater Weight Loss Later in Life Associated with Increased Risk of Mild Cognitive Impairment
In a population-based, prospective study of subjects ≥ 70 years of age, increasing weight loss per decade from midlife to late-life was associated with an increased risk of incident mild cognitive impairment.
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Wheat Causes Intestinal Immune Activation in Some Patients Without Celiac Disease
Some patients without celiac disease may exhibit wheat sensitivity with demonstrated intestinal epithelial cell damage.
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Too Little of a Good Thing Can Be a Bad Thing
A healthy lifestyle may substantially reduce the burden of cancer.
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FDA Actions
In this section: FDA approves generic influenza treatment; major pharma loses statin battle; FDA gives thumbs up to agonist to treat type 2 diabetes; agency green lights dry eye disease solution; and approves over-the-counter acne treatment.
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Study: Knee Replacement Can Lead to Chronic Opioid Use
Total knee replacement is the surgical procedure most commonly associated with chronic opioid use in opioid-naïve patients.
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Report: Certain Drugs Cause, Exacerbate Heart Failure
New recommendations for clinicians treating heart failure patients include comprehensive medication reconciliation, evaluating risks and benefits of every medication, and discontinuing medications when possible.
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Top Pharmaceutical Company Suffers Blow After Major Drug Fails Phase III Trial
The checkpoint inhibitor nivolumab failed a Phase III trial as monotherapy in patients with previously untreated non-small cell lung cancer.
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Wide Rhythm in a Patient with Chest Pain
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Clinical Briefs
In this section: A new statin toxicity emerges; debates about diabetes screening continues; and exploring links between chronic fatigue and serious outcomes.
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Obeticholic Acid Tablets (Ocaliva)
Obeticholic acid provides an FDA-approved treatment option for patients who have not responded adequately to or are unable to tolerate ursodeoxycholic acid.