Clinical
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FDA Actions
In this section: FDA removes black box warning from Chantix; approves first biosimilar to Humira; issues warning about hepatitis C drug; and green lights first drug to treat common childhood form of muscular dystrophy.
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Experts Withdraw Support for Codeine in Children
After years of debate, the American Academy of Pediatrics has issued a Clinical Report recommending against the use of codeine for cough or pain in children, regardless of age.
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New Erectile Dysfunction Data Counter Previous Studies
This study will be a relief for men who take 5-alpha reductase inhibitors, since previous studies suggested erectile dysfunction may be a significant problem with these drugs.
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New Study Compares Leading Atrial Fibrillation Treatments
The authors concluded that rivaroxaban use for atrial fibrillation was associated with significantly higher rates of intracranial hemorrhage and major extracranial bleeding.
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The Importance of Low Uric Acid in Gout Patients
Consistent abolition of acute flares has been confirmed only when uric acid levels < 6.0 mg/dL are maintained over the long term.
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Does Technology Accelerate Weight Loss?
Trial participants randomized to add-on gadgetry actually experienced less weight loss than those who simply received traditional diet and exercise advice.
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Gabapentin and Pregabalin Effective for Refractory Chronic Pruritus
Promising trial results support consideration of gabapentin, pregabalin, or both for patients presenting with refractory pruritus.
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USPSTF Endorses TB Screening for High-risk Individuals
Despite the absence of TB screening trials that confirm benefits, since treatment of latent TB prevents progression to active TB, a moderate degree of benefit should be achieved through screening.
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COPD Patients Who May Need Intensified Smoking Cessation
Identifying the characteristics that predict less success with smoking cessation may allow clinicians an opportunity to redouble efforts in these same individuals.
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Early Response to Exercise in Depressed Patients
We may be better able to capture the potential for beneficial effects of exercise in depression by early identification of responders.