Clinical
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A Hidden Rhythm
The only clinical information available for this tracing is that the ECG was obtained from an older woman. Without any other background, where should we go from here?
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Involvement of the Peripheral Nervous System in Neurolymphomatosis
Lymphoma that presents with peripheral neuropathy is a challenging diagnosis. Diagnosis and treatment often are delayed, but they can be facilitated by early consideration and imaging with fluorodeoxyglucose-positron emission tomography. Early diagnosis and hematologic treatment may be effective.
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Somatic Variants in Ras/Raf/MAPK Pathway Play a Role in Mesial Temporal Lobe Epilepsy
Eleven somatic variants enriched in the hippocampus were detected in a group of patients with drug-resistant mesial temporal lobe epilepsy (MTLE). Most somatic variants are mutations in the Ras/Raf/mitogen-activated protein kinase (MAPK) pathway. Overactivation of the Ras/Raf/MAPK pathway was detected in MTLE with somatic variants.
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Trichloroethylene Exposure Has Been Linked to an Increased Risk of Parkinson’s Disease
Preliminary evidence suggests trichloroethylene is a potential environmental risk factor for Parkinson’s disease. Further research is needed to confirm this association.
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Lovastatin for Reducing Risk and Delaying Onset of ALS
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease without available treatments that significantly alter the disease course. Using Medicare databases and pharmacy records, with multiple logistic regression models, researchers studied three candidate drugs (lovastatin, sulfasalazine, and telmisartan) that were identified as possible therapies for ALS and their effects on SOD1G93A transgenic mice. Animal testing showed a delay in disease onset and prolonged survival in mice treated with a mouse-equivalent dose of lovastatin 40 mg, but showed no benefit from the other two candidate drugs.
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A Primer on Excessive Daytime Sleepiness and Narcolepsy
Many new drugs are coming on the market to treat daytime sleepiness, as well as insomnia, as the prevalence of sleep disorders continues to grow in modern society. Neurologists should familiarize themselves with these disorders and the various ways to treat them safely.
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Oral Medication to Treat ‘Hot Flashes’ Could Be Available Soon
The FDA has approved the first neurokinin 3 receptor antagonist to alleviate symptoms associated with moderate to severe vasomotor symptoms caused by menopause.
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Straight Shooting: Primary Care and the Reduction of Harm from Firearms
Gun violence is a leading cause of premature death in the United States. More than 45,000 Americans died from gun violence in 2020, a substantial increase from previous years. The scope of the problem is such that the American Public Health Association has identified gun violence as a public health problem and recommends a “comprehensive public health approach.” Primary care providers (PCPs) are in a unique position to lead the way in a campaign to reduce harm from firearms.
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Sleep Apnea Appears to Age Brain Faster
Researchers observed patients who spent less time in deep sleep showed biomarkers indicative of poor neurological health.
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Does Alcohol Provide Any Health Benefit?
The authors of a large systematic review and meta-analysis concluded there is no health benefit from moderate alcohol intake.