Clinical
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Rituximab Treatment in Neuromyelitis Optica Spectrum Disorders
Based on a meta-analysis and review of rituximab use in the treatment of neuromyelitis optica spectrum disorders, the authors reported that rituximab was efficacious in reducing relapse rate and disability, but cautioned about potential side effects and adverse events, especially when considering rituximab as first-line therapy.
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How Useful is Amyloid PET Imaging in the Diagnosis of Dementia?
In a prospective, observational study in multiple centers in Italy, amyloid PET imaging was shown to be negative in 35% of patients who met clinical criteria for a diagnosis of Alzheimer’s disease.
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Bull’s-eye Sign in Parsonage-Turner Syndrome
High-resolution MRI of peripheral nerves can help make an accurate diagnosis of the Parsonage-Turner syndrome by revealing a bull’s-eye sign in cross-sectional images of the nerve.
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Electrical Brain Stimulation for Primary Progressive Aphasia
In this pilot study, transcranial direct current stimulation appeared to improve some aspects of verbal object identification and naming in a small number of patients with primary progressive aphasia.
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Zika Virus Infection and Guillain-Barré Syndrome: The Evidence Grows
A recent Zika outbreak in Colombia was associated with a significant increase in Guillain-Barré syndrome (GBS) rates, with laboratory evidence of definite or probable Zika infection in more than half of the GBS cases.
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High-flow Nasal Cannula vs. Noninvasive Ventilation in Postextubation Failure
SYNOPSIS: In this multicenter, randomized, clinical trial of critically ill adults at high risk for reintubation, high-flow conditioned oxygen therapy was not inferior to noninvasive mechanical ventilation with regard to preventing reintubation and postextubation respiratory failure within 72 hours of extubation.
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Diastolic Blood Pressure Goals
SYNOPSIS: An analysis of the community-based ARIC study showed that low diastolic blood pressures were associated with higher baseline and subsequent troponin T levels and adverse cardiac events, but not stroke.
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Pulmonary Embolism Common Cause for Syncope in Hospitalized Patients
Syncope is a chief complaint for which neurologists often are consulted. In most cases, the neurological concern is possible stroke or an epileptic seizure. However, a variety of cardiopulmonary problems are most often the underlying cause of syncope, including cardiac arrhythmias and pulmonary embolism. The investigators of this study reviewed the clinical records of 560 patients (mean age of 76 years) who were admitted to the hospital with syncope.
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New Paradigm in the Management of Massive and Submassive Pulmonary Embolism
SYNOPSIS: A multidisciplinary pulmonary embolism response team is a sustainable option to improve care for severe pulmonary embolism.
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VRE and MRSA: Should We Stop Routine Contact Precautions?
SYNOPSIS: The value of routine contact precautions for VRE and MRSA is strongly challenged.