Clinical
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Restricting Fluoroquinolone Use Reduces Clostridium difficile Infection More Than Infection Control Methods
An observational study from England showed that restricting fluoroquinolone use reduced incidence of Clostridium difficile infection more than would be predicted by improved infection control methods alone.
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Bright-light Therapy for Daytime Sleepiness in Parkinson’s Disease Patients
Light therapy has been shown to be beneficial in treating excessive daytime sleepiness in Parkinson’s disease patients and also may improve sleep quality.
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Pregabalin Not Effective for Reducing Pain in Acute or Chronic Sciatica
An Australian study of 207 patients suffering from acute and chronic clinically diagnosed sciatica did not find that treatment with pregabalin for eight weeks reduced pain at eight or 52 weeks.
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Obesity and Endometrial Cancer
Obesity is a major risk factor for endometrial cancer as well as for other major comorbidities.
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Oral Contraceptives and Quality of Life
In this three-month randomized, double-blind trial comparing oral contraceptives to placebo, the authors found a small decrease in general well-being scores but no effect on depressive symptoms. The short time period and small effect size introduce doubt into the validity of these findings.
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Contraindications to Home Birth
A new study of neonatal death rates over a four-year period in the United States has identified two new contraindications to home birth.
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Pelvic Floor Changes in First Pregnancy: How Do They Affect Quality of Life?
Nulliparous women experience worsening urinary incontinence, fecal incontinence, and perineal pain in pregnancy. Urinary incontinence symptoms are associated with a negative effect on quality of life.
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Hot Flashes: A Marker of Increased Cardiovascular Risk?
Among otherwise healthy midlife women, the presence of frequent hot flashes was associated with impaired endothelial function, a risk factor for cardiovascular disease.
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FDA Actions
In this section: The agency approves new treatment for postmenopausal osteoporosis, greenlights generic treatment for hypercholesterolemia, give approval to a second biosimilar to infliximab, restricts the use of codeine and tramadol in children, and allows valbenazine to treat tardive dyskinesia.
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Testing the Effects of Statins on Muscles
How common are statin-related muscle symptoms?