Clinical
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Yoga for Lumbago?
A review of randomized, controlled trials of treatments for chronic non-specific, low back pain revealed that yoga provides improvements in back-related function compared to non-exercise controls at intermediate time points, and in pain scores in the short term. Also, yoga seems to be comparable to exercise interventions, although the quality of evidence was low enough to preclude us from knowing for sure.
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Saffron and Depression: What Do We Know and Where Do We Go?
Saffron studies, while still preliminary, show potential for use of this ancient spice in combatting mild-moderate depression.
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Treatment of Intracerebral Hemorrhage Guided by the ‘Spot Sign’
Although the “spot sign” is a predictor of early hematoma expansion, selective treatment of this group with aggressive antihypertensive therapy did not alter hematoma size or neurological outcome.
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Direct DNA Sequencing of Dominant Cerebellar Ataxias
Current genetic testing techniques with DNA sequencing can diagnose the molecular-genetic causes for the majority of dominantly inherited cerebellar ataxias.
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Severe Olfactory Impairment Is Associated With Preclinical Alzheimer’s Disease
In this cross-sectional, population-based, cohort study of 829 cognitively normal participants, abnormal neuroimaging biomarkers known to be associated with Alzheimer’s disease were associated with severe olfactory impairment.
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Plasma α-Synuclein Is a Leading Candidate Biomarker in Parkinson’s Disease
In this cross-sectional study, plasma alpha-synuclein levels were higher in individuals with Parkinson’s disease than controls, and correlated with cognitive decline.
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Tacrolimus for Treatment of Myasthenia Gravis
A large observational study performed in Korea suggests that tacrolimus is an effective immunomodulating, steroid-sparing medication for the treatment of myasthenia gravis.
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Prediction of Survival After Cardiac Arrest Using Pupillometry
Automated infrared pupillometry holds promise as a quantitative, reproducible measure that aids in determining neurological prognosis after cardiac arrest and coma.
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Distinguishing Ischemic from Non-ischemic Cardiomyopathy Clinically
SYNOPSIS: This cardiac catheterization-based study of patients with newly diagnosed reduced left ventricular ejection fraction of unknown etiology showed that 15% had ischemic cardiomyopathy and they could be identified by clinical characteristics and an ECG-based risk score.
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B-type Natriuretic Peptide Is Less Useful in Elderly Patients with Dyspnea
SYNOPSIS: Among patients ≥ 80 years of age presenting with acute dyspnea, B-type natriuretic peptide level was not useful for differentiating cardiac vs. respiratory etiologies when added to a model of clinical predictors.